Gastric secretion, proinflammatory cytokines and epidermal growth factor (EGF) in the delayed healing of lingual and gastric ulcerations by testosterone.

Gastric secretion, proinflammatory cytokines and epidermal growth factor (EGF) in the delayed healing of lingual and gastric ulcerations by testosterone. Research Abstract Details 

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Gastric secretion, proinflammatory cytokines and epidermal growth factor (EGF) in the delayed healing of lingual and gastric ulcerations by testosterone. Abstract Text:

A Machowska,T Brzozowski,Z Sliwowski,M Pawlik,P C Konturek,R Pajdo,A Szlachcic,D Drozdowicz,M Schwarz,J Stachura,S J Konturek,W W Pawlik,A Machowska,T Brzozowski,Z Sliwowski,M Pawlik,P C Konturek,R Pajdo,A Szlachcic,D Drozdowicz,M Schwarz,J Stachura,S J Konturek,W W Pawlik,

Hormonal fluctuations are known to predispose ulceration of the upper gastrointestinal tract, but to date no comparative study of their effects on the healing of pre-existing ulcers in the oral cavity and stomach has been made. We studied the effects of depletion of testosterone and of EGF on the healing of acetic acid-induced ulcers using rats having undergone bilateral orchidectomy and/or salivectomy respectively. We measured alterations in gastric acid secretion and blood flow at ulcer margins, as well as plasma levels of testosterone, gastrin and the proinflammatory cytokines IL-1beta and TNF-alpha. Testosterone (0.01-10 mg/kg/day i. m.) dose-dependently delayed oral and gastric ulcer healing. When applied in an optimal dose of 1 mg/kg/day, this hormone significantly raised gastric acid secretion and plasma IL-1beta and TNF-alpha levels. Attenuation of plasma testosterone levels via bilateral orchidectomy inhibited gastric acid secretion and accelerated the healing of oral and gastric ulcers, while increasing plasma gastrin levels and these effects were reversed by testosterone. Salivectomy raised plasma testosterone levels, and delayed oral and gastric ulcer healing. Treatment of salivectomised animals with testosterone further inhibited ulcer healing, and this effect was counteracted by EGF. We propose that testosterone delays ulcer healing via a fall in blood flow at the ulcer margin, a rise in plasma levels of IL-1beta and TNF-alpha and, in the case of gastric ulcers, an increase in gastric acid secretion. EGF released from the salivary glands plays an important role in limitation of the deleterious effects of testosterone on ulcer healing.

Gastric secretion, proinflammatory cytokines and epidermal growth factor (EGF) in the delayed healing of lingual and gastric ulcerations by testosterone. Publishing Authors By Initials

A Machowska,T Brzozowski,Z Sliwowski,M Pawlik,PC Konturek,R Pajdo,A Szlachcic,D Drozdowicz,M Schwarz,J Stachura,SJ Konturek,WW Pawlik,A Machowska,T Brzozowski,Z Sliwowski,M Pawlik,PC Konturek,R Pajdo,A Szlachcic,D Drozdowicz,M Schwarz,J Stachura,SJ Konturek,WW Pawlik,

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Gastric secretion, proinflammatory cytokines and epidermal growth factor (EGF) in the delayed healing of lingual and gastric ulcerations by testosterone. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Inflammopharmacology

VOLUME: 16

Page Numbers: 40-7

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ISSN: 0925-4692

DAY: 7

MONTH: Feb

YEAR: 2008

Gastric secretion, proinflammatory cytokines and epidermal growth factor (EGF) in the delayed healing of lingual and gastric ulcerations by testosterone. Information

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LANGUAGE: eng

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AFFILIATION: Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531, Cracow, Poland.

Country: Switzerland

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MEDLINETA: Inflammopharmacology

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