GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling.

GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Research Abstract Details 

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GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Abstract Text:

N Saeki,D H Kim,T Usui,K Aoyagi,T Tatsuta,K Aoki,K Yanagihara,M Tamura,H Mizushima,H Sakamoto,K Ogawa,M Ohki,T Shiroishi,T Yoshida,H Sasaki,

Defining apoptosis-regulatory cascades of the epithelium is important for understanding carcinogenesis, since cancer cells are considered to arise as a result of the collapse of the cascades. We previously reported that a novel gene GASDERMIN (GSDM) is expressed in the stomach but suppressed in gastric cancer cell lines. Furthermore, in this study, we demonstrated that GSDM is expressed in the mucus-secreting pit cells of the gastric epithelium and frequently silenced in primary gastric cancers. We found that GSDM has a highly apoptotic activity and its expression is regulated by a transcription factor LIM domain only 1 (LMO1) through a sequence to which Runt-related transcription factor 3 (RUNX3) binds, in a GSDM promoter region. We observed coexpression of GSDM with LMO1, RUNX3 and type II transforming growth factor-beta receptor (TGF-betaRII) in the pit cells, and found that TGF-beta upregulates the LMO1- and GSDM-expression in the gastric epithelial cell line and induces apoptosis, which was confirmed by the finding that the apoptosis induction is inhibited by suppression of each LMO1-, RUNX3- and GSDM expression, respectively. The present data suggest that TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis.

GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Publishing Authors By Initials

N Saeki,DH Kim,T Usui,K Aoyagi,T Tatsuta,K Aoki,K Yanagihara,M Tamura,H Mizushima,H Sakamoto,K Ogawa,M Ohki,T Shiroishi,T Yoshida,H Sasaki,

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GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Oncogene

VOLUME: 26

Page Numbers: 6488-98

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 30

MONTH: 04

YEAR: 2007

GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Information

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LANGUAGE: eng

NlmUniqueID: 8711562

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AFFILIATION: Center for Medical Genomics, Genetics Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.

Country: England

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MEDLINETA: Oncogene

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