GAP-43 is key to mitotic spindle control and centrosome-based polarization in neurons.

GAP-43 is key to mitotic spindle control and centrosome-based polarization in neurons. Research Abstract Details 

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GAP-43 is key to mitotic spindle control and centrosome-based polarization in neurons. Abstract Text:

In neurons, the position of the centrosome during final mitosis marks the point of emergence of the future axon. However, the molecular underpinnings linking centrosome position to axon emergence are unknown. GAP-43 is a calmodulin-binding IQ motif protein that regulates neuronal cytoskeletal architecture by interacting with F-actin in a phosphorylation dependent manner. Here we show that GAP-43 is associated with the centrosome and plays a critical role in mitosis and acquisition of neuronal polarity in cerebellar granule neurons. In the absence of GAP-43, the centrosome position is delinked from process outgrowth and is only capable of mediating morphological polarization, however molecular specification of the axonal compartment does not take place. These results show that GAP-43 is required to link centrosome position to process outgrowth in order to generate neuronal polarity in cerebellar granule cells.

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GAP-43 is key to mitotic spindle control and centrosome-based polarization in neurons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell cycle (Georgetown, Tex.)

VOLUME: 7

Page Numbers: 348-57

Journal Abbreviation: Cell Cycle

ISSN: 1551-4005

DAY: 1

MONTH: 11

YEAR: 2007

GAP-43 is key to mitotic spindle control and centrosome-based polarization in neurons. Information

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LANGUAGE: eng

NlmUniqueID: 101137841

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Grant and Affiliation Information for GAP-43 is key to mitotic spindle control and centrosome-based polarization in neurons.

AFFILIATION: National Brain Research Center, Manesar, Haryana, India.

Country: United States

AGENCY: United States PHS

GRANT: R03TWO6050

ACRONYM: NS

MEDLINETA: Cell Cycle

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