Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis.

Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. Research Abstract Details 

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Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. Abstract Text:

Minoo Battiwalla,Yiyuan Wu,Rajinder P S Bajwa,Marija Radovic,Nikolaos G Almyroudis,Brahm H Segal,Paul K Wallace,Ryotaro Nakamura,Swaminathan Padmanabhan,Theresa Hahn,Philip L McCarthy,Minoo Battiwalla,Yiyuan Wu,Rajinder P S Bajwa,Marija Radovic,Nikolaos G Almyroudis,Brahm H Segal,Paul K Wallace,Ryotaro Nakamura,Swaminathan Padmanabhan,Theresa Hahn,Philip L McCarthy,

Cytomegalovirus (CMV) disease-related mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients has dramatically declined because of ganciclovir prophylaxis and preemptive therapeutic strategies. However, ganciclovir has not improved overall survival in randomized studies despite effectively preventing overt CMV disease. Moreover, recurrent posttransplant CMV antigenemia, associated with prolonged ganciclovir exposure, is a predictor of increased relapse of malignancy. We examined the hypothesis that ganciclovir itself may have a negative impact on immune reconstitution by testing the effect of ganciclovir on normal human lymphocytes in vitro. T-lymphocyte activation and proliferation, as measured by PHA-induced (3)H-thymidine uptake, was greatly reduced at therapeutic concentrations of ganciclovir (10 microg/mL) but not for foscarnet (300 microM/L). Moreover, ganciclovir impaired bromodeoxyuridine incorporation in proliferating lymphocytes, but did not impair lymphocyte survival or induce lymphocyte apoptosis. Collectively, these results show that ganciclovir suppresses T-lymphocyte proliferation in vitro by inhibiting DNA synthesis; with implications for T-lymphocyte function following allogeneic BMT.

Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. Publishing Authors By Initials

M Battiwalla,Y Wu,RP Bajwa,M Radovic,NG Almyroudis,BH Segal,PK Wallace,R Nakamura,S Padmanabhan,T Hahn,PL McCarthy,M Battiwalla,Y Wu,RP Bajwa,M Radovic,NG Almyroudis,BH Segal,PK Wallace,R Nakamura,S Padmanabhan,T Hahn,PL McCarthy,

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Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biology of blood and marrow transplantation : jour

VOLUME: 13

Page Numbers: 765-70

Journal Abbreviation: Biol. Blood Marrow Transplant.

ISSN: 1083-8791

DAY: 7

MONTH: 05

YEAR: 2007

Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. Information

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LANGUAGE: eng

NlmUniqueID: 9600628

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Grant and Affiliation Information for Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis.

AFFILIATION: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14202, USA. minoo.battiwalla@roswellpark.org <minoo.battiwalla@roswellpark.org>

Country: United States

AGENCY: United States NCI

GRANT: 5 P30 CA016056-29

ACRONYM: CA

MEDLINETA: Biol Blood Marrow Transplant

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