Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma.

Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma. Research Abstract Details 

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Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma. Abstract Text:

Lihui Wei,Yubin Miao,Fabio Gallazzi,Thomas P Quinn,Michael J Welch,Amy L V?vere,Jason S Lewis,Lihui Wei,Yubin Miao,Fabio Gallazzi,Thomas P Quinn,Michael J Welch,Amy L V?vere,Jason S Lewis,

INTRODUCTION: Diagnosis of malignant melanoma is critical, since a patient's prognosis is poor. Previous studies have shown that (64)Cu- and (86)Y-DOTA-ReCCMSH(Arg(11)) have the potential for early detection of malignant melanoma by exploiting the sensitivity and high resolution of positron emission tomography (PET). This encouraged us to investigate DOTA-ReCCMSH(Arg(11)) labeled with another beta(+)-emitting radionuclide, (68)Ga. METHODS: DOTA-ReCCMSH(Arg(11)) was successfully labeled with (68)Ga at pH 3.8-4 at 85 degrees C. Acute biodistribution and small-animal PET imaging studies were performed in mice bearing B16/F1 melanoma tumor. RESULTS: Biodistribution studies showed moderate receptor-mediated tumor uptake, fast nontarget organ clearance and high tumor to nontarget tissue ratios. Preadministration of d-lysine significantly reduced kidney uptake without affecting the uptake of the agent in the tumor. Small-animal PET images showed that the tumor could be clearly visualized at all time points examined (0.5-2 h) with the standardized uptake value analysis following a similar trend as the biodistribution data. CONCLUSIONS: The preliminary data obtained suggest that (68)Ga-DOTA-ReCCMSH(Arg(11)) is a promising PET imaging agent for early detection of malignant melanoma.

Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma. Publishing Authors By Initials

L Wei,Y Miao,F Gallazzi,TP Quinn,MJ Welch,AL V?vere,JS Lewis,L Wei,Y Miao,F Gallazzi,TP Quinn,MJ Welch,AL V?vere,JS Lewis,

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Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nuclear medicine and biology

VOLUME: 34

Page Numbers: 945-53

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ISSN: 0969-8051

DAY: 4

MONTH: 09

YEAR: 2007

Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma. Information

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LANGUAGE: eng

NlmUniqueID: 9304420

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Grant and Affiliation Information for Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma.

AFFILIATION: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Country: England

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MEDLINETA: Nucl Med Biol

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