Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival.

Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Research Abstract Details 

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Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Abstract Text:

M T Elola,C Wolfenstein-Todel,M F Troncoso,G R Vasta,G A Rabinovich,

Galectins are a taxonomically widespread family of glycan-binding proteins, defined by at least one conserved carbohydrate-recognition domain with a canonical amino acid sequence and affinity for beta-galactosides. Because of their anti-adhesive as well as pro-adhesive extracellular functions, galectins appear to be a novel class of adhesion-modulating proteins collectively known as matricellular proteins (which include thrombospondin, SPARC, tenascin, hevin, and disintegrins). Accordingly, galectins can display de-adhesive effects when presented as soluble proteins to cells in a strong adhesive state. In this context, the de-adhesive properties of galectins should be considered as physiologically relevant as the proadhesive effects of these glycan-binding proteins. This article focuses on the roles of mammalian galectins in cell adhesion, spreading, and migration, and the crossregulation of these functions. Although careful attention should be paid when examining individual galectin functions due to overlapping distributions, these intriguing glycan-binding proteins offer promising possibilities for the treatment and intervention of a wide variety of pathological processes, including cancer, inflammation, and autoimmunity.

Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Publishing Authors By Initials

MT Elola,C Wolfenstein-Todel,MF Troncoso,GR Vasta,GA Rabinovich,

For similar carbohydrates: polysaccharides research abstracts see: carbohydrates: polysaccharides research

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Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Journal Published:

PUBLICATION TYPE: Review

Journal: Cellular and molecular life sciences : CMLS

VOLUME: 64

Page Numbers: 1679-700

Journal Abbreviation: Cell. Mol. Life Sci.

ISSN: 1420-682X

DAY: 3

MONTH: Jul

YEAR: 2007

Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Information

Number of References: 163

LANGUAGE: eng

NlmUniqueID: 9705402

Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Keywords Mesh Terms:

KEYWORDS: Polysaccharides

MESH TERMS: metabolism

Chemical & Substance for Abstract: Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Information

Substance Name: Polysaccharides

Registry Number: 0

Grant and Affiliation Information for Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival.

AFFILIATION: Instituto de Química y Fisicoquímica Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, C1123, Buenos Aires, Argentina.

Country: Switzerland

AGENCY: United States NIGMS

GRANT: R01 GM070589-01

ACRONYM: GM

MEDLINETA: Cell Mol Life Sci

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