Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue.

Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue. Research Abstract Details 

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Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue. Abstract Text:

Kohji Kiwaki,Colleen M Novak,Daniel K Hsu,Fu-Tong Liu,James A Levine,Kohji Kiwaki,Colleen M Novak,Daniel K Hsu,Fu-Tong Liu,James A Levine,

OBJECTIVE: Some cytokines and mediators of inflammation can alter adiposity through their effects on adipocyte number. To probe the molecular basis of obesity, this study determined whether galectin-3 was present in adipose tissue and investigated its effects on fat cell number. RESEARCH METHODS AND PROCEDURES: In the first study, obesity-prone C57BL/6J mice were fed with high-fat (58%) diet. Epididymal fat pads were collected at Day 0, Day 60, and Day 120 after the start of high-fat feeding. RESULTS: Levels of adipocyte galectin-3 protein, determined using Western blot analysis, increased as the mice became obese. Galectin-3 mRNA and protein were then detected in human adipose tissue, primarily in the preadipocyte fraction. It was found that recombinant human galectin-3 stimulated proliferation of primary cultured preadipocytes as well as DNA synthesis through lectin-carbohydrate interaction. DISCUSSION: Galectin-3, which has been known to play a versatile role especially in immune cells, might play a role also in adipose tissue and be associated with the pathophysiology of obesity.

Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue. Publishing Authors By Initials

K Kiwaki,CM Novak,DK Hsu,FT Liu,JA Levine,K Kiwaki,CM Novak,DK Hsu,FT Liu,JA Levine,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Obesity (Silver Spring, Md.)

VOLUME: 15

Page Numbers: 32-9

Journal Abbreviation:

ISSN: 1930-7381

DAY: 3

MONTH: Jan

YEAR: 2007

Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101264860

Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue. Information

Substance Name: Galectin 3

Registry Number: 0

Grant and Affiliation Information for Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue.

AFFILIATION: Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

Country: United States

AGENCY: United States PHS

GRANT: 63226

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MEDLINETA: Obesity (Silver Spring)

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