Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke.

Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke. Research Abstract Details 

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Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke. Abstract Text:

Satoru Ishibashi,Toshihiko Kuroiwa,Masanori Sakaguchi,Liyuan Sun,Toshihiko Kadoya,Hideyuki Okano,Hidehiro Mizusawa,Satoru Ishibashi,Toshihiko Kuroiwa,Masanori Sakaguchi,Liyuan Sun,Toshihiko Kadoya,Hideyuki Okano,Hidehiro Mizusawa,

Galectin-1 (Gal-1) has recently been identified as a key molecule that plays important roles in the regulation of neural progenitor cell proliferation in two neurogenic regions: the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone of the hippocampal dentate gyrus. To test the hypothesis that Gal-1 contributes to adult neurogenesis after focal ischemia, we studied the temporal profile of endogenous Gal-1 expression and the effects of human recombinant Gal-1 on neurogenesis and neurological functions in an experimental focal ischemic model. In the normal brain, Gal-1 expression was observed only in the SVZ. In the ischemic brain, Gal-1 expression was markedly upregulated in the SVZ and the area of selective neuronal death around the infarct in the striatum. The temporal profile of Gal-1 expression was correlated with that of neural progenitor cell proliferation in the SVZ of the ischemic hemisphere. Double-labeling studies revealed that Gal-1 was localized predominantly in both reactive astrocytes and SVZ astrocytes. Administration of Gal-1, which is known to have carbohydrate-binding ability, into the lateral ventricle increased neurogenesis in the ipsilateral SVZ and improved sensorimotor dysfunction after focal ischemia. By contrast, blockade of Gal-1 in the SVZ by the administration of anti-Gal-1 neutralizing antibody strongly inhibited neurogenesis and diminished neurological function. These results suggest that Gal-1 is one of the principal regulators of adult SVZ neurogenesis through its carbohydrate-binding ability and provide evidence that Gal-1 protein has a role in the improvement of sensorimotor function after stroke.

Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke. Publishing Authors By Initials

S Ishibashi,T Kuroiwa,M Sakaguchi,L Sun,T Kadoya,H Okano,H Mizusawa,S Ishibashi,T Kuroiwa,M Sakaguchi,L Sun,T Kadoya,H Okano,H Mizusawa,

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Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental neurology

VOLUME: 207

Page Numbers: 302-13

Journal Abbreviation: Exp. Neurol.

ISSN: 0014-4886

DAY: 17

MONTH: 07

YEAR: 2007

Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke. Information

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LANGUAGE: eng

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AFFILIATION: Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Country: United States

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MEDLINETA: Exp Neurol

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