Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption.

Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption. Research Abstract Details 

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Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption. Abstract Text:

Simon Mercier,Christian St-Pierre,Isabelle Pelletier,Michel Ouellet,Michel J Tremblay,Sachiko Sato,

Following primary infection with human immunodeficiency virus type-1 (HIV-1), macrophages are thought to play an important role, as they are one of the first target cells the virus encounters and can also sustain a significant production of viruses over extended periods of time. While the interaction between the primary cellular receptor CD4 and the virus-encoded external envelope glycoprotein gp120 initiates the infection process, it has been suggested that various host factors are exploited by HIV-1 to facilitate adsorption onto the cell surface. Macrophages and other cells found at the infection site can secrete a soluble mammalian lectin, galectin-1, which binds to beta-galactoside residues through its carbohydrate recognition domain. Being a dimer, galectin-1 can cross-link ligands expressed on different constituents to mediate adhesion between cells or between cells and pathogens. We report here that galectin-1, but not galectin-3, increased HIV-1 infectivity in monocyte-derived macrophages (MDMs). This phenomenon was likely due to an enhancement of virus adsorption kinetics, which facilitates HIV-1 entry. The fusion inhibitors T-20 and TAK779 remained effective at reducing infection even in the presence of galectin-1, indicating that the galectin-1-mediated effect is occurring at a step prior to fusion. Together, our data suggest that galectin-1 can facilitate HIV-1 infection in MDMs by promoting early events of the virus replicative cycle (i.e. adsorption).

Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption. Publishing Authors By Initials

S Mercier,C St-Pierre,I Pelletier,M Ouellet,MJ Tremblay,S Sato,

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Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virology

VOLUME: 371

Page Numbers: 121-9

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 29

MONTH: 10

YEAR: 2007

Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption.

AFFILIATION: Research Center for Infectious Diseases, CHUL Research Center, Quebec, Canada; Faculty of Medicine, Laval University, Quebec, Canada.

Country: United States

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MEDLINETA: Virology

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