Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats.

Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats. Research Abstract Details 

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Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats. Abstract Text:

Elizabeth Hohnadel,Kristy Bouchard,Alvin V Terry,

Acetylcholinesterase inhibitors (AChEIs) are currently being evaluated as adjunctive therapy for the cognitive dysfunction of schizophrenia. This core symptom of schizophrenia has often been attributed to impaired attention and abnormal sensory motor gating, features that are also found in Huntington's Disease, autism, and several other psychiatric and neurological disorders. The ability to improve prepulse inhibition (PPI) of the acoustic startle response may predict the efficacy of compounds as cognitive enhancers. In this study, PPI was disrupted in Wistar rats in three pharmacologic models: dopamine receptor agonism by apomorphine, NMDA receptor antagonism by MK801, or muscarinic acetylcholine receptor antagonism by scopolamine. We then evaluated the commonly used AChEIs, donepezil (0.5, 1.0, or 2.0mg/kg) and galantamine (0.3, 1.0, or 3.0mg/kg) for the capacity to improve PPI in each model. Under vehicle conditions, the prepulse stimuli (75, 80 and 85dB) inhibited the startle response to a 120dB auditory stimulus in a graded fashion. Galantamine (depending on dose) improved PPI deficits in all three PPI disruption models, whereas donepezil ameliorated PPI deficits induced by scopolamine and apomorphine, but was not effective in the MK801 model. These results indicate that some AChEIs may have the potential to improve cognition in schizophrenia by improving auditory sensory gating.

Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats. Publishing Authors By Initials

E Hohnadel,K Bouchard,AV Terry,

For similar diagnosis: diagnostic techniques and procedures: diagnostic techniques, neurological: neurologic examination: reflex: startle reaction research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic techniques, neurological: neurologic examination: reflex: startle reaction research

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MEDLINE DATE:

Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuropharmacology

VOLUME: 52

Page Numbers: 542-51

Journal Abbreviation: Neuropharmacology

ISSN: 0028-3908

DAY: 12

MONTH: 10

YEAR: 2006

Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 236217

Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats. Keywords Mesh Terms:

KEYWORDS: Startle Reaction

MESH TERMS: radiation effects

Chemical & Substance for Abstract: Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats. Information

Substance Name: Dizocilpine Maleate

Registry Number: 77086-22-7

Grant and Affiliation Information for Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats.

AFFILIATION: College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.

Country: England

AGENCY: United States NIMH

GRANT: R01 MH066233-03

ACRONYM: MH

MEDLINETA: Neuropharmacology

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