Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review.

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review. Abstract Text:

The present review summarizes clinical and experimental data concerning the possible effects of a prebiotic mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides. The results from several studies, made up of over 400 preterm and term infants, clearly demonstrate that the prebiotic mixture under examination specifically stimulates the growth of bifidobacteria and lactobacilli and reduces the growth of pathogens. As a consequence of the changed intestinal flora by the dietary galacto-oligosaccharides and fructo-oligosaccharides, the faecal pH values and the short-chain fatty acid pattern were similar to those found in breastfed infants. In addition, the stool consistency was the same as in breastfed infants. In vitro experiments have demonstrated that the specific short-chain fatty acid pattern, at a pH similar to that found in faecal samples of breastfed infants, reduces the growth of pathogens in a dose-dependent manner but does not influence the growth of bifidobacteria and lactobacilli. In an animal vaccination model, the prebiotic mixture improved the response to vaccination. In an allergy model (sensitization by ovalbumin), the allergic reaction was reduced by the prebiotic mixture. The data obtained from animal experiments are in agreement with preliminary data from clinical trials which indicate a reduced allergic response (reduced plasma IgE/IgG4 ratio) and reduced episodes of upper airway infection during the first year of life. CONCLUSION: Experimental evidence demonstrates that the prebiotic mixture employed in these studies modulates the intestinal flora and modulates the immune system as human milk does. There are sufficient experimental data to put forward the hypothesis that substances like the prebiotic mixture under study will substantially contribute to the improvement of the protective properties of infant formulas.

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review. Publishing Authors By Initials

For similar food and beverages: food: dietary supplements: probiotics research abstracts see: food and beverages: food: dietary supplements: probiotics research

PUBMED ID PMID:

MEDLINE DATE:

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta paediatrica (Oslo, Norway : 1992). Supplement

VOLUME: 94

Page Numbers: 22-6

Journal Abbreviation: Acta Paediatr Suppl

ISSN: 0803-5326

DAY: 12

MONTH: Oct

YEAR: 2005

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review. Information

Number of References: 33

LANGUAGE: eng

NlmUniqueID: 9315043

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review. Keywords Mesh Terms:

KEYWORDS: Probiotics

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review. Information

Substance Name: Oligosaccharides

Registry Number: 0

Grant and Affiliation Information for Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review.

AFFILIATION: Neonatal Intensive Care Unit, Department of Clinical and Experimental Medicine, University of Ferrara, Italy. fnrslv@unife.it

Country: Norway

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Acta Paediatr Suppl

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review Related Publications

• Advances in the modulation of the microbial ecology of the gut in early infancy.
• Considerations and approaches in determining the protein and energy composition of preterm infant formulas.
• Dietary supplements for the lactating mother: influence on the trace element content of milk.
• Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review.
• Intestinal microflora in early infancy: composition and development.
• Lactoferrin in infant formulae.
• Milk formulae for the normal infant. II. Recommendations, energy, physical characteristics and protein composition.
• Milk formulae for the normal infant. III. Lipids and trace elements.
• Which role for prebiotics at weaning?
• [Aspects of the epithelium of the crypt in some tonsillar neoplasms.]
• [Clinical, anatomical & pathological concepts of in situ carcinoma of larynx.]
• [Various aspects of laryngeal cancer for the general practitioner.]