Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned.

Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned. Research Abstract Details 

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Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned. Abstract Text:

Georges Saab,Ali Abu-Alfa,

OBJECTIVE: Nephrogenic systemic fibrosis (NSF) is a rare multisystemic fibrosing disorder that principally affects the skin but may affect other organs of patients with renal insufficiency. The purpose of our study was to identify any common risk factors and determine whether i.v. gadodiamide is associated with the development of NSF. MATERIALS AND METHODS: A retrospective chart review was performed for all 12 patients diagnosed with NSF at our institution between 2000 and 2006 to identify the clinical manifestations, timing, and dose of gadodiamide administration; dialysis records; concurrent medications; comorbid conditions and surgeries; laboratory findings; imaging findings; and clinical outcome. A review of the dialysis and MR records between 2000 and 2006 showed 559 MRI examinations on 168 dialysis patients (including 301 contrast-enhanced examinations). RESULTS: NSF was diagnosed by clinical findings and tissue diagnosis. All 12 patients had renal insufficiency--eight with dialysis-dependent chronic renal insufficiency and four with acute hepatorenal syndrome. All 12 patients developed skin fibrosis within 2-11 weeks after gadodiamide administration. The odds ratio for development of NSF after gadodiamide exposure was 22.3. No other common event or exposure could be found. Four patients had abnormal scintigraphic bone scans with skin and muscle uptake and lower-extremity MRI finding of edema in the muscles, intermuscular fascia, and skin. Despite the fact that 10 patients were dialyzed within 2 days of gadodiamide administration, this did not prevent the development of NSF. CONCLUSION: Development of NSF was strongly associated with gadodiamide administration in the setting of either acute hepatorenal syndrome or dialysis-dependent chronic renal insufficiency.

Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned. Publishing Authors By Initials

G Saab,A Abu-Alfa,

For similar skin and connective tissue diseases: skin diseases research abstracts see: skin and connective tissue diseases: skin diseases research

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Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJR. American journal of roentgenology

VOLUME: 188

Page Numbers: 586-92

Journal Abbreviation:

ISSN: 1546-3141

DAY: 15

MONTH: Feb

YEAR: 2007

Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7708173

Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned. Keywords Mesh Terms:

KEYWORDS: Skin Diseases

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned. Information

Substance Name: Gadolinium DTPA

Registry Number: 80529-93-7

Grant and Affiliation Information for Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned.

AFFILIATION: Department of Radiology, Loma Linda University Medical Center, 11234 Anderson St., MC Room 2605, Loma Linda, CA 92354, USA.

Country: United States

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MEDLINETA: AJR Am J Roentgenol

REFSOURCE: AJR Am J Roentgenol. 2007 Sep;189(3):W16

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