[Gabapentin (Neurontin): a new possibility in the add-on therapy of partial epilepsies]

[Gabapentin (Neurontin): a new possibility in the add-on therapy of partial epilepsies] Research Abstract Details 

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[Gabapentin (Neurontin): a new possibility in the add-on therapy of partial epilepsies] Abstract Text:

Gabapentin is a new antiepileptic drug for add-on therapy in patients above the age of 12 years with otherwise refractory partial seizures. Its unknown molecular mode of action is probably related to amino-acid-related binding sites in the brain. There are no hints to toxicologic effects or damage of the hematopoietic system, liver, or kidney in man. With the exception of a rather short elimination half life and dose-limited abortion, the pharmacokinetic data are very favourable. Due to lack of protein binding and metabolization, there are no major interactions with antiepileptic or other drugs. Efficacy has been demonstrated in three multicenter, placebo controlled trials involving a total of 705 patients. Secondarily generalized seizures seem to be the most likely to respond to 900 to 1800 mg/day, followed by complex partial and simple partial seizures. Tolerance is good, and serious side effects have not been observed up to now.

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[Gabapentin (Neurontin): a new possibility in the add-on therapy of partial epilepsies] Journal Published:

PUBLICATION TYPE: Review

Journal: Praxis

VOLUME: 85

Page Numbers: 84-93

Journal Abbreviation:

ISSN: 1661-8157

DAY: 23

MONTH: Jan

YEAR: 1996

[Gabapentin (Neurontin): a new possibility in the add-on therapy of partial epilepsies] Information

Number of References: 106

LANGUAGE: ger

NlmUniqueID: 101468093

[Gabapentin (Neurontin): a new possibility in the add-on therapy of partial epilepsies] Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: drug therapy

Chemical & Substance for Abstract: [Gabapentin (Neurontin): a new possibility in the add-on therapy of partial epilepsies] Information

Substance Name: gabapentin

Registry Number: 60142-96-3

Grant and Affiliation Information for [Gabapentin (Neurontin): a new possibility in the add-on therapy of partial epilepsies]

AFFILIATION: Schweizerische Epilepsie-Klinik, Zürich.

Country: SWITZERLAND

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MEDLINETA: Praxis (Bern 1994)

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