GABAergic processes mediate thermal prolongation of the laryngeal reflex apnea in decerebrate piglets.

GABAergic processes mediate thermal prolongation of the laryngeal reflex apnea in decerebrate piglets. Research Abstract Details 

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GABAergic processes mediate thermal prolongation of the laryngeal reflex apnea in decerebrate piglets. Abstract Text:

Ines ,Luxi Xia,J C Leiter,Donald Bartlett,

We tested the hypotheses that elevated body temperature would prolong reflex apnea following electrical stimulation of the superior laryngeal nerve (SLN) in decerebrate neonatal piglets and that thermal prolongation of reflex apnea after stimulation of the SLN depended on GABAergic mechanisms. These studies were conducted in 13 decerebrate piglets (age 3-15 days). The SLN was stimulated at approximately 1.5 times the threshold stimulus level for 10 s starting at the beginning of inspiration. We measured the duration of the apnea and respiratory disruption that followed SLN stimulation. Elevating body temperature prolonged the duration of the apnea and respiratory disruption that followed SLN stimulation, and treatment with antagonists of gama-aminobutyric acid A-type (GABAA) receptors reversed the thermal prolongation of reflex apnea and the period of respiratory disruption even though body temperature remained elevated. We conclude that elevated body temperature enhances or amplifies GABAergic mechanisms that prolong the respiratory inhibition following electrical stimulation of the SLN.

GABAergic processes mediate thermal prolongation of the laryngeal reflex apnea in decerebrate piglets. Publishing Authors By Initials

I ,L Xia,JC Leiter,D Bartlett,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

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MEDLINE DATE:

GABAergic processes mediate thermal prolongation of the laryngeal reflex apnea in decerebrate piglets. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Respiratory physiology & neurobiology

VOLUME: 156

Page Numbers: 229-33

Journal Abbreviation:

ISSN: 1569-9048

DAY: 27

MONTH: 10

YEAR: 2006

GABAergic processes mediate thermal prolongation of the laryngeal reflex apnea in decerebrate piglets. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101140022

GABAergic processes mediate thermal prolongation of the laryngeal reflex apnea in decerebrate piglets. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: physiology

Chemical & Substance for Abstract: GABAergic processes mediate thermal prolongation of the laryngeal reflex apnea in decerebrate piglets. Information

Substance Name: gamma-Aminobutyric Acid

Registry Number: 56-12-2

Grant and Affiliation Information for GABAergic processes mediate thermal prolongation of the laryngeal reflex apnea in decerebrate piglets.

AFFILIATION: Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, United States.

Country: Netherlands

AGENCY: United States NICHD

GRANT: HD 36379

ACRONYM: HD

MEDLINETA: Respir Physiol Neurobiol

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