GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina.

GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina. Abstract Text:

Chih-Tien Wang,Aaron G Blankenship,Anastasia Anishchenko,Justin Elstrott,Michael Fikhman,Shigetada Nakanishi,Marla B Feller,

Ambient GABA modulates firing patterns in adult neural circuits by tonically activating extrasynaptic GABA(A) receptors. Here, we demonstrate that during a developmental period when activation of GABA(A) receptors causes membrane depolarization, tonic activation of GABA(A) receptors blocks all spontaneous activity recorded in retinal ganglion cells (RGCs) and starburst amacrine cells (SACs). Bath application of the GABA(A) receptor agonist muscimol blocked spontaneous correlated increases in intracellular calcium concentration and compound postsynaptic currents in RGCs associated with retinal waves. In addition, GABA(A) receptor agonists activated a tonic current in RGCs that significantly reduced their excitability. Using a transgenic mouse in which green fluorescent protein is expressed under the metabotropic glutamate receptor subtype 2 promoter to target recordings from SACs, we found that GABA(A) receptor agonists blocked compound postsynaptic currents and also activated a tonic current. GABA(A) receptor antagonists reduced the holding current in SACs but not RGCs, indicating that ambient levels of GABA tonically activate GABA(A) receptors in SACs. GABA(A) receptor antagonists did not block retinal waves but did alter the frequency and correlation structure of spontaneous RGC firing. Interestingly, the drug aminophylline, a general adenosine receptor antagonist used to block retinal waves, induced a tonic GABA(A) receptor antagonist-sensitive current in outside-out patches excised from RGCs, indicating that aminophylline exerts its action on retinal waves by direct activation of GABA(A) receptors. These findings have implications for how various neuroactive drugs and neurohormones known to modulate extrasynaptic GABA(A) receptors may influence spontaneous firing patterns that are critical for the establishment of adult neural circuits.

GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina. Publishing Authors By Initials

CT Wang,AG Blankenship,A Anishchenko,J Elstrott,M Fikhman,S Nakanishi,MB Feller,

For similar nervous system: neural pathways: afferent pathways: visual pathways research abstracts see: nervous system: neural pathways: afferent pathways: visual pathways research

PUBMED ID PMID:

MEDLINE DATE:

GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 9130-40

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 22

MONTH: Aug

YEAR: 2007

GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina. Keywords Mesh Terms:

KEYWORDS: Visual Pathways

MESH TERMS: physiology

Chemical & Substance for Abstract: GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina. Information

Substance Name: Aminophylline

Registry Number: 317-34-0

Grant and Affiliation Information for GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina.

AFFILIATION: Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.

Country: United States

AGENCY: United States NEI

GRANT: R01EY13528

ACRONYM: EY

MEDLINETA: J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

GABAA receptor-mediated signaling alters the structure of spontaneous activity in the developing retina Related Publications

• A report of oral extramedullary acute myeloid leukaemia (AML) in an 8-year-old girl with newly diagnosed AML-M4Eo.
• Burn nursing is nursing.
• Cattle with thymic lymphoma and haematoma of the ventral neck: a comparison of findings.
• Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
• Changes of photosynthetic traits in beech saplings (Fagus sylvatica) under severe drought stress and during recovery.
• GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina.
• Imaging second messenger dynamics in developing neural circuits.
• Impact of an exceptionally hot dry summer on photosynthetic traits in oak (Quercus pubescens) leaves.
• Incarcerated inguinal hernia as the presenting feature of carcinoma of unknown primary site.
• Mangrove recruitment after forest disturbance is facilitated by herbaceous species in the Caribbean.
• Molecular dynamics simulations as a complement to nuclear magnetic resonance and X-ray diffraction measurements.
• Orbital abscess as a complication of odontogenic infection. A case report and review of the literature.
• Pharmacological effects of ephedrine alkaloids on human alpha(1)- and alpha(2)-adrenergic receptor subtypes.
• Preservation of follicle mantle in follicular lymphoma.
• Protein-calorie undernutrition in the nursing home.
• Provider-sponsored ADSs: reducing antitrust liability after Maricopa.
• Reducing the public health burden of low vision in the Rhode Island elderly.
• Role of cholesterol and polyunsaturated chains in lipid-protein interactions: molecular dynamics simulation of rhodopsin in a realistic membrane environment.
• Rumination syndrome: an emerging case scenario.
• Serum fatty acid profile of elderly tube-fed men in a nursing home.
• Support Vector Machines for detecting recovery from knee replacement surgery using quantitative gait measures.
• Tethered yohimbine analogs as selective human alpha2C-adrenergic receptor ligands.
• The noncatalytic triad of alpha-amylases: a novel structural motif involved in conformational stability.
• Twinrix vaccination schedules among injecting drug users.
• Ultrasonographic findings in cows with right displacement of the abomasum and abomasal volvulus.
• [(Not) a brief awakening]
• [Chronic trichomonas infections in the male. Their significance for fertility disorders]
• [Effect of some phenothiazine derivatives, especially megaphen, on gas exchange in white rats.]
• [Reconstruction of the female breast with free transverse lower abdominal flap as perforator flap]
• [The face-neck lift]