G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease.

G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease. Research Abstract Details 

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G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease. Abstract Text:

Alfredo Ulloa-Aguirre,Jo Ann Janovick, Miranda,P Michael Conn,

The primary function of cell surface receptors is to recognize specific chemical signals from other substances and produce a biological response. Point mutations in cell surface receptors may result in production of misfolded proteins that are translated but do not reach their proper functional destination in the cell. Also, for some G-protein-coupled receptors, large amounts of wild-type receptor may be destroyed without arriving at the plasma membrane (PM). For the human gonadotropin-releasing hormone receptor, this "inefficiency" has resulted from strong and convergent evolutionary pressure, producing receptor molecules that are sensitive to single changes in chemical charge and are delicately balanced between expression at the PM or retention/degradation in the endoplasmic reticulum. This Perspective focuses on the evolved mechanisms that control PM expression of this receptor at this post-translational level.

G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease. Publishing Authors By Initials

A Ulloa-Aguirre,JA Janovick,AL Miranda,PM Conn,

For similar proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, lhrh research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, lhrh research

PUBMED ID PMID:

MEDLINE DATE:

G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease. Journal Published:

PUBLICATION TYPE: Review

Journal: ACS chemical biology

VOLUME: 1

Page Numbers: 631-8

Journal Abbreviation: ACS Chem. Biol.

ISSN: 1554-8937

DAY: 21

MONTH: Nov

YEAR: 2006

G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease. Information

Number of References: 26

LANGUAGE: eng

NlmUniqueID: 101282906

G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease. Keywords Mesh Terms:

KEYWORDS: Receptors, LHRH

MESH TERMS: metabolism

Chemical & Substance for Abstract: G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease. Information

Substance Name: Receptors, LHRH

Registry Number: 0

Grant and Affiliation Information for G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease.

AFFILIATION: Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006, USA.

Country: United States

AGENCY: United States NICHD

GRANT: TW/HD-00668

ACRONYM: HD

MEDLINETA: ACS Chem Biol

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