G-protein-coupled receptor heterodimerization: assay technologies to clinical significance.

G-protein-coupled receptor heterodimerization: assay technologies to clinical significance. Research Abstract Details 

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G-protein-coupled receptor heterodimerization: assay technologies to clinical significance. Abstract Text:

Toby Kent,Cheryl McAlpine,Sahar Sabetnia,Jeremy Presland,

The concept of G-protein-coupled receptor (GPCR) oligomerization has existed for many years, but has only recently received scrutiny from the pharmaceutical industry. The new interest in this theory has arisen not only because technologies to exploit GPCR oligomers are now available, but also because GPCR oligomerization has the potential to explain previously anomalous pharmacology and to provide an array of new therapeutic targets. The emergence of higher order GPCR organization adds a layer of complexity in the context of cellular control, and indeed drug discovery. This review outlines the current knowledge surrounding the oligomerization of GPCRs and describes effective assays for exploiting oligomerization in drug discovery. The clinical significance of oligomerization and the most promising strategies for therapeutically targeting GPCR oligomers are discussed.

G-protein-coupled receptor heterodimerization: assay technologies to clinical significance. Publishing Authors By Initials

T Kent,C McAlpine,S Sabetnia,J Presland,

For similar investigative techniques: technology, pharmaceutical research abstracts see: investigative techniques: technology, pharmaceutical research

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G-protein-coupled receptor heterodimerization: assay technologies to clinical significance. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in drug discovery & development

VOLUME: 10

Page Numbers: 580-9

Journal Abbreviation:

ISSN: 1367-6733

DAY: 26

MONTH: Sep

YEAR: 2007

G-protein-coupled receptor heterodimerization: assay technologies to clinical significance. Information

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LANGUAGE: eng

NlmUniqueID: 100887519

G-protein-coupled receptor heterodimerization: assay technologies to clinical significance. Keywords Mesh Terms:

KEYWORDS: Technology, Pharmaceutical

MESH TERMS: physiology

Chemical & Substance for Abstract: G-protein-coupled receptor heterodimerization: assay technologies to clinical significance. Information

Substance Name: Receptors, G-Protein-Coupled

Registry Number: 0

Grant and Affiliation Information for G-protein-coupled receptor heterodimerization: assay technologies to clinical significance.

AFFILIATION: Department of Molecular Pharmacology, Organon Laboratories Ltd, Newhouse, Scotland, ML1 5SH, UK. T.Kent@organon.co.uk

Country: England

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MEDLINETA: Curr Opin Drug Discov Devel

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