G-CSF after myocardial infarction accelerates angiogenesis and reduces fibrosis in swine.

G-CSF after myocardial infarction accelerates angiogenesis and reduces fibrosis in swine. Research Abstract Details 

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G-CSF after myocardial infarction accelerates angiogenesis and reduces fibrosis in swine. Abstract Text:

OBJECTIVE: Recent studies have suggested that granulocyte colony-stimulating factor (G-CSF) may improve cardiac function after acute myocardial infarction (AMI) by accelerating angiogenesis or cardiomyogenesis, but negative results and side effect of G-CSF have also been reported. However, no previous studies have used large animal models of ischemia/reperfusion to investigate the effect and side effect of G-CSF after AMI. METHODS: The diagonal branch of the left anterior descending coronary artery of swine was balloon-occluded for 1 h and then reperfused. The animals of the G-CSF group were injected with G-CSF subcutaneously (5.0 microg/kg/day) for 6 days after MI and then sacrificed after 4 weeks. The control group received the same volume of saline. RESULTS: There were no differences between the groups in the rate of thrombotic obstruction or progression of stenosis lesion in coronary angiography. The ejection fraction and end-diastolic volume in the G-CSF group were not significantly improved over the control values. The fibrotic area was significantly smaller in the G-CSF group than in the controls (P<0.05), and the numbers of vessels counted in anti-von Willebrand factor and anti-alpha-smooth muscle actin-stained sections were significantly larger (P<0.005 and P<0.05, respectively). The expression of collagen III mRNA was significantly lower in the G-CSF group than in the control in the infarct (P<0.0005) and border areas (P<0.005), and TGF-beta mRNA was significantly lower in the G-CSF group in the border area (P<0.05). CONCLUSIONS: G-CSF could modify the healing process after AMI by accelerating angiogenesis in a swine ischemia/reperfusion model. At the dose administered, however, G-CSF did not seem to improve the global cardiac function.

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G-CSF after myocardial infarction accelerates angiogenesis and reduces fibrosis in swine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of cardiology

VOLUME: 127

Page Numbers: 166-73

Journal Abbreviation: Int. J. Cardiol.

ISSN: 1874-1754

DAY: 9

MONTH: 08

YEAR: 2007

G-CSF after myocardial infarction accelerates angiogenesis and reduces fibrosis in swine. Information

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LANGUAGE: eng

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Grant and Affiliation Information for G-CSF after myocardial infarction accelerates angiogenesis and reduces fibrosis in swine.

AFFILIATION: Third Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan.

Country: Netherlands

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MEDLINETA: Int J Cardiol

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