G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study.

G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study. Research Abstract Details 

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G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study. Abstract Text:

Azad R Bhuiyan,Wei Chen,Sathanur R Srinivasan,Janet Rice,Nancy Mock,Rong Tang,M Gene Bond,Eric Boerwinkle,Gerald S Berenson,

BACKGROUND: The adverse association between blood pressure and carotid artery intima-media thickness (IMT), a surrogate measure of subclinical atherosclerosis, is well-known. However, whether the G-6A polymorphism of the angiotensinogen (AGT) gene, a candidate gene of hypertension and vascular remodeling, modulates this relationship is unknown. METHODS: In 662 white and black subjects aged 25 to 43 years (73.4% white, 39.7% male), common carotid IMT was measured by B-mode ultrasonography. RESULTS: The variant A-6 allele frequency was higher in blacks than in whites (0.850 v 0.448, P < .0001). In a bivariate analysis, there were no differences in mean arterial blood pressure and common carotid IMT between carriers and noncarriers of the G allele in whites, blacks, or the total sample, after adjusting for gender, age, and race. In a multivariable regression analysis that included the status of the G allele (carriers versus noncarriers) along with gender, age, mean arterial blood pressure, body mass index, LDL cholesterol, triglycerides:HDL cholesterol ratio, homeostasis model assessment of insulin resistance, smoking, and race (in the total sample), mean arterial blood pressure was significantly and adversely associated with common carotid IMT in whites, blacks, and the total sample. This adverse positive relationship between mean arterial blood pressure and common carotid IMT was noted among noncarriers but not carriers of the G allele (comparison of slopes, P = .02) in the total sample. Although the interaction was not significant (P = .2 and P = .05 in whites and blacks, respectively), a trend similar to that in the total sample was found in both races. CONCLUSIONS: In a recessive manner, the genetic variant (G-6A) of the AGT gene modulates the association between blood pressure and carotid IMT in young adults.

G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study. Publishing Authors By Initials

AR Bhuiyan,W Chen,SR Srinivasan,J Rice,N Mock,R Tang,MG Bond,E Boerwinkle,GS Berenson,

For similar musculoskeletal system: muscles: muscle, smooth: muscle, smooth, vascular: tunica media research abstracts see: musculoskeletal system: muscles: muscle, smooth: muscle, smooth, vascular: tunica media research

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G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of hypertension : journal of the

VOLUME: 20

Page Numbers: 1073-8

Journal Abbreviation: Am. J. Hypertens.

ISSN: 0895-7061

DAY: 29

MONTH: Oct

YEAR: 2007

G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8803676

G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study. Keywords Mesh Terms:

KEYWORDS: Tunica Media

MESH TERMS: ultrasonography

Chemical & Substance for Abstract: G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study. Information

Substance Name: Angiotensinogen

Registry Number: 11002-13-4

Grant and Affiliation Information for G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study.

AFFILIATION: Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University, New Orleans, LA 70112, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-38844

ACRONYM: HL

MEDLINETA: Am J Hypertens

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