Fusogenic activity of various water-soluble polymers.

Fusogenic activity of various water-soluble polymers. Research Abstract Details 

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Fusogenic activity of various water-soluble polymers. Abstract Text:

N Nakajima,Y Ikada,

The fusogenic activity of seven water-soluble polymers was investigated using L929 cells in a monolayer state. Among these polymers, only two, poly(ethylene glycol) (PEG) and EPAN 680 were capable of inducing the membrane fusion of L929 cells. EPAN 680 is an ABA type block copolymer composed of 80% ethylene oxide(A) and 20% propylene oxide(B) sequences with a total molecular weight of 8800. Evaluation of the polymer hydrophobicity indicated that there was no clear correlation between it and the fusogenic activity of the polymer, although highly hydrophobic polymers caused cell shrinkage without membrane fusion. Differential scanning calorimetry on these polymers strongly suggested that hydration of the polymers in culture medium had a large effect on their fusogenic activity. It was concluded that the assembly of cell membranes, stabilized by water molecules, was disturbed by strong interaction with the polymer molecules having a strong hydration power, resulting in membrane fusion.

Fusogenic activity of various water-soluble polymers. Publishing Authors By Initials

N Nakajima,Y Ikada,

For similar water research abstracts see: water research

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Fusogenic activity of various water-soluble polymers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 6

Page Numbers: 751-9

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 1994

Fusogenic activity of various water-soluble polymers. Information

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LANGUAGE: eng

NlmUniqueID: 9007393

Fusogenic activity of various water-soluble polymers. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: chemistry

Chemical & Substance for Abstract: Fusogenic activity of various water-soluble polymers. Information

Substance Name: Water

Registry Number: 7732-18-5

Grant and Affiliation Information for Fusogenic activity of various water-soluble polymers.

AFFILIATION: Research Center for Biomedical Engineering, Kyoto University, Japan.

Country: NETHERLANDS

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MEDLINETA: J Biomater Sci Polym Ed

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