Further validation of the alcohol dependence scale as an index of severity.

Further validation of the alcohol dependence scale as an index of severity. Research Abstract Details 

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Further validation of the alcohol dependence scale as an index of severity. Abstract Text:

Andrew J Saxon,Daniel R Kivlahan,Suzanne Doyle,Dennis M Donovan,

OBJECTIVE: The Alcohol Dependence Scale (ADS) yields continuous scores purported to reflect the severity of the dependence syndrome. We evaluated the concurrent validity of the ADS as a general measure of severity and the screening accuracy of the total score and subscales to detect Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), physiological dependence. METHOD: Treatment-seeking, alcohol-dependent individuals entering the Combining Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study (N = 1,372; 69% men) completed the ADS, diagnostic interviews, and other measures before randomization. Analyses of variance tested differences between ADS quartiles on alcohol- related measures. Areas under the receiver operating characteristic (AUROC) curve assessed screening accuracy for DSM-IV physiological dependence (tolerance or withdrawal) or withdrawal alone. RESULTS: ADS quartiles differed on age, other demographics, and prior treatment episodes. Linear correlation showed moderate to large magnitude associations with alcohol-related self-report measures and most indices of consumption. ADS quartiles differed significantly on proportion with DSM-IV physiological dependence, but AUROC curves indicated that the ADS had limited accuracy as a continuous measure to detect DSMIV physiological dependence (AUROC = .75 [95% confidence interval {CI}: .70-.79] and .67 [95% CI: .60-.74] for men and women, respectively; p = .08) or withdrawal alone (AUROC = .77 [95% CI: .74-.80] and .74 [95% CI: .69-.79] for men and women, respectively; p = .30). Screening accuracy was comparably limited based on ADS subscales reflecting psychoperceptual or psychophysical withdrawal. CONCLUSIONS: The ADS reflected variation in symptom severity but did not adequately identify physiological dependence or withdrawal in treatment-seeking individuals with DSM-IV alcohol dependence.

Further validation of the alcohol dependence scale as an index of severity. Publishing Authors By Initials

AJ Saxon,DR Kivlahan,S Doyle,DM Donovan,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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Further validation of the alcohol dependence scale as an index of severity. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of studies on alcohol and drugs

VOLUME: 68

Page Numbers: 149-56

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ISSN: 0096-882X

DAY: 3

MONTH: Jan

YEAR: 2007

Further validation of the alcohol dependence scale as an index of severity. Information

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LANGUAGE: eng

NlmUniqueID: 101295847

Further validation of the alcohol dependence scale as an index of severity. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: statistics & numerical data

Chemical & Substance for Abstract: Further validation of the alcohol dependence scale as an index of severity. Information

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Grant and Affiliation Information for Further validation of the alcohol dependence scale as an index of severity.

AFFILIATION: Department of Psychiatry and Behavioral Sciences, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA. Andrew.saxon@med.va.gov

Country: United States

AGENCY: United States NIAAA

GRANT: 5 U10 AA11799

ACRONYM: AA

MEDLINETA: J Stud Alcohol Drugs

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