Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models.

Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models. Abstract Text:

Dana Stevenson-Abouelnasr,Ghaleb A Husseini,William G Pitt,

The kinetics of the release of Doxorubicin from Pluronic P105 micelles during ultrasonication and its subsequent re-encapsulation upon cessation of insonation were investigated. Four mechanisms are proposed to explain the acoustically-triggered Doxorubicin (Dox) release and re-encapsulation from Pluronic P105 micelles. The four mechanisms are: micelle destruction; destruction of cavitating nuclei; reassembly of micelles, and the re-encapsulation of Dox. The first mechanism, the destruction of micelles during insonation, causes the release of Dox into solution. The micelles are destroyed because of cavitation events produced by collapsing nuclei, or bubbles in the insonated solution. The second mechanism, the slow destruction of cavitating nuclei, results in a slow partial recovery phase, when a small amount of Dox is re-encapsulated. The third and fourth mechanisms, the reassembly of micelles and the re-encapsulatin of Dox, are independent of ultrasound. These two mechanism are responsible for maintaining the drug release at a partial level, and for recovery after insonation ceases. A normal distribution was used to describe micellar size. Parameters for the model were determined based upon the best observed fit to experimental data. The resulting model provides a good approximation to experimental data for the release of Dox from Pluronic P105 micelles.

Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models. Publishing Authors By Initials

D Stevenson-Abouelnasr,GA Husseini,WG Pitt,

For similar natural sciences: physics: acoustics: ultrasonics research abstracts see: natural sciences: physics: acoustics: ultrasonics research

PUBMED ID PMID:

MEDLINE DATE:

Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Colloids and surfaces. B, Biointerfaces

VOLUME: 55

Page Numbers: 59-66

Journal Abbreviation:

ISSN: 0927-7765

DAY: 16

MONTH: 11

YEAR: 2006

Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9315133

Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models. Keywords Mesh Terms:

KEYWORDS: Ultrasonics

MESH TERMS: chemistry

Chemical & Substance for Abstract: Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models. Information

Substance Name: Doxorubicin

Registry Number: 23214-92-8

Grant and Affiliation Information for Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models.

AFFILIATION: Chemical Engineering Department, American University of Sharjah, Sharjah, United Arab Emirates.

Country: Netherlands

AGENCY: United States NCI

GRANT: R01 CA098138-02

ACRONYM: CA

MEDLINETA: Colloids Surf B Biointerfaces

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models Related Publications

• A SURVEY OF THE CHEMISTRY OF VISUAL PIGMENTS.
• A propensity-matched study of the association of low serum potassium levels and mortality in chronic heart failure.
• A study of regressive place assimilation in spontaneous speech and its implications for spoken word recognition.
• Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death.
• Beam expansion in linear constant period gratings.
• Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons.
• Carpal tunnel syndrome in the mucopolysaccharidoses and mucolipidoses.
• Cholecystosteatosis: an explanation for increased cholecystectomy rates.
• Comments on: Saturation biopsy for detecting and characterizing prostate cancer; and A review of targeted screening for prostate cancer: introducing the IMPACT study.
• Cortical evoked response to gaps in noise: within-channel and across-channel conditions.
• EEG features of cortical dysplasia in children.
• Enzymic catalysis of the keto-enol tautomerization of phenylpyruvic acids.
• Ezetimibe ameliorates cholecystosteatosis.
• Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models.
• High dietary carbohydrates decrease gallbladder volume and enhance cholesterol crystal formation.
• Insulin resistance causes human gallbladder dysmotility.
• Leptin regulates gallbladder genes related to absorption and secretion.
• Low-frequency ultrasound increases outer membrane permeability of Pseudomonas aeruginosa.
• Modeling and sensitivity analysis of acoustic release of Doxorubicin from unstabilized pluronic P105 using an artificial neural network model.
• N-terminal pro-B-type natriuretic peptide concentrations >=100 ng/l increased risk of all-cause mortality.
• Normal MR appearance of the pituitary gland in the first 2 years of life.
• Pancreatic cystic neuroendocrine tumors: preoperative diagnosis with endoscopic ultrasound and fine-needle immunocytology.
• Pathology of inhalational anthrax infection in the african green monkey.
• Percutaneous coronary intervention plus optimal medical therapy was not more effective than medical therapy alone in stable CAD.
• Pioglitazone increases gallbladder volume in insulin-resistant obese mice.
• Recent advances in the physiology of vitamin A.
• Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound.
• Some aspects of anomalous vision.
• The art and science of artificial infant feeding.
• Time trends for HIV-1 antiretroviral resistance among antiretroviral-experienced and naive pregnant women in New York City during 1991 to early 2001.