Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba.

Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba. Research Abstract Details 

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Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba. Abstract Text:

OBJECTIVE: To establish the association of HLA alleles (ie, HLA-DR1, HLA-DR4, and HLA-DR7) with individuals with skin cancer on the tropical island of Saba. This island was chosen because most of the white population has fair skin and excessive exposure to sunlight, which results in a high prevalence of skin cancer. DESIGN: HLA typing was performed in 124 white individuals with histologically proven basal cell and/or squamous cell carcinoma and in control subjects. Skin type, the presence of freckling, and the number of actinic keratoses were determined. SETTING: Population-based study. SUBJECTS: Inhabitants of Saba with and without skin cancer. MAIN OUTCOME MEASURE: Presence of HLA-DR1, HLA-DR4, and HLA-DR7 alleles. RESULTS: Associations of HLA alleles with basal cell and squamous cell carcinoma have been reported. The presence of the HLA-DR7 allele was positively associated with the development of basal cell carcinoma (odds ratio, 3.8; 95% confidence interval, 1.1-13.4). Adjustment for skin type, which is a potentially confounding factor for the association between HLA alleles and skin cancer, did not substantially alter this association. No other associations between HLA alleles and skin cancer were found, possibly because of the small size of the study population. CONCLUSION: This study presented further evidence for an association between HLA-DR7 and basal cell carcinoma. Arch Dermatol. 2000;136:1019-1022

Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba. Publishing Authors By Initials

For similar geographic locations: americas: caribbean region: west indies research abstracts see: geographic locations: americas: caribbean region: west indies research

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Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of dermatology

VOLUME: 136

Page Numbers: 1019-22

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Aug

YEAR: 2000

Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba. Keywords Mesh Terms:

KEYWORDS: West Indies

MESH TERMS: genetics

Chemical & Substance for Abstract: Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba. Information

Substance Name: HLA-DR7 Antigen

Registry Number: 0

Grant and Affiliation Information for Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba.

AFFILIATION: Department of Dermatology, Leiden University Medical Center, The Netherlands. dermatol@euronet.nl

Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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