Fundus changes in central retinal artery occlusion.

Fundus changes in central retinal artery occlusion. Research Abstract Details 

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Fundus changes in central retinal artery occlusion. Abstract Text:

Sohan Singh Hayreh,M Bridget Zimmerman,

PURPOSE: To investigate systematically the ophthalmoscopic fundus findings associated with central retinal artery occlusion (CRAO). METHODS: The study included 240 consecutive patients (248 eyes) with CRAO. The eyes underwent detailed fundus evaluation and stereoscopic color fundus photography at initial and follow-up visits. Patients without evidence of giant cell arteritis were advised to have carotid Doppler imaging and echocardiography to determine the source of emboli. CRAO was classified into 3 types: permanent CRAO (175 eyes), permanent CRAO with cilioretinal artery sparing (35 eyes), and transient CRAO (38 eyes). In the three types of CRAO, acute-phase and late-phase changes in the retina, optic disk, and retinal vessels were evaluated. RESULTS: The main findings during the initial examination in our clinic for permanent CRAO were retinal opacity in the posterior pole (58%), cherry-red spot (90%), box-carring (19%), retinal arterial attenuation (32%), and optic disk edema (22%) and pallor (39%). The most frequent findings identified at the late stage, based on survivorship curves, were optic atrophy (91%), retinal arterial attenuation (58%), cilioretinal collaterals (18%), and macular retinal pigment epithelial changes (11%). Compared with permanent CRAO, permanent CRAO with cilioretinal artery sparing was associated with a lower incidence of all macular and optic disk abnormalities. For transient CRAO, the incidence of initial findings varied greatly compared with the other types. Intraarterial emboli were observed in 20% of patients. Carotid Doppler evaluation identified carotid vascular plaques in 67% of patients tested and hemodynamically significant (>50%) obstruction in 32%. Four percent of CRAOs presented with simultaneous bilateral onset. CONCLUSIONS: The type and incidence of fundus findings at the initial visit and in the late phase of CRAO vary by its type. This study confirms that retinal opacity is predominantly evident in the posterior retina, that optic disk findings at presentation are common, that CRAO associated with normal-appearing retinal vessels and/or optic disk is not rare, and that observation of emboli is infrequent. Clinicians should be aware of the various presentation findings during the acute and late stages of CRAO and its various types. A complete picture of CRAO is provided by combined information of our clinical and experimental studies of CRAO.

Fundus changes in central retinal artery occlusion. Publishing Authors By Initials

SS Hayreh,MB Zimmerman,

For similar cardiovascular system: blood vessels: retinal vessels: retinal vein research abstracts see: cardiovascular system: blood vessels: retinal vessels: retinal vein research

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Fundus changes in central retinal artery occlusion. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Retina (Philadelphia, Pa.)

VOLUME: 27

Page Numbers: 276-89

Journal Abbreviation:

ISSN: 0275-004X

DAY: 3

MONTH: Mar

YEAR: 2007

Fundus changes in central retinal artery occlusion. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309919

Fundus changes in central retinal artery occlusion. Keywords Mesh Terms:

KEYWORDS: Retinal Vein

MESH TERMS: pathology

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Grant and Affiliation Information for Fundus changes in central retinal artery occlusion.

AFFILIATION: Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa, USA. sohan-hayreh@uiowa.edu

Country: United States

AGENCY: United States NEI

GRANT: R01-EY-1151

ACRONYM: EY

MEDLINETA: Retina

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