Functions of MAP kinases: insights from gene-targeting studies.

Functions of MAP kinases: insights from gene-targeting studies. Research Abstract Details 

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Functions of MAP kinases: insights from gene-targeting studies. Abstract Text:

Keisuke Kuida,Diane M Boucher,

Mitogen-activated protein kinases (MAPKs) comprise a family of well-conserved serine/threonine kinases that control a vast array of physiological functions in a number of organisms ranging from yeast to mammals. Recently gene-targeting experiments have shed light on in vivo functions of MAPKs. In particular, embryos deficient in extracellular signal-regulated kinase (ERK) 2 lack mesoderm differentiation and placental angiogenesis. Knockout mice for c-Jun amino-terminal kinases have revealed roles for these kinases in neural apoptosis and activation/differentiation of T cells. Deletion of p38alpha MAPK results in angiogenic defects in the placenta and peripheral vessels. ERK5-deficient embryos are embryonic lethal due to defects in angiogenesis and cardiovascular development. Although these results have provided new insights for MAPK research, development and analysis of conditional knockout mice are required in order to investigate roles of MAPKs, especially, in other biological processes such as disease pathogenesis.

Functions of MAP kinases: insights from gene-targeting studies. Publishing Authors By Initials

K Kuida,DM Boucher,

For similar genetic phenomena: phenotype research abstracts see: genetic phenomena: phenotype research

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Functions of MAP kinases: insights from gene-targeting studies. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 135

Page Numbers: 653-6

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jun

YEAR: 2004

Functions of MAP kinases: insights from gene-targeting studies. Information

Number of References: 43

LANGUAGE: eng

NlmUniqueID: 376600

Functions of MAP kinases: insights from gene-targeting studies. Keywords Mesh Terms:

KEYWORDS: Phenotype

MESH TERMS: metabolism

Chemical & Substance for Abstract: Functions of MAP kinases: insights from gene-targeting studies. Information

Substance Name: Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Functions of MAP kinases: insights from gene-targeting studies.

AFFILIATION: Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, MA 02139, USA. keisuke_kuida@vrtx.com

Country: Japan

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MEDLINETA: J Biochem

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