Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis. Short communication.

Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis. Short communication. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis. Short communication. Abstract Text:

Gonadotropin-releasing hormone (GnRH) is a ten-amino acid peptide hormone that plays pivotal roles in reproduction in vertebrates and octopus. Recently, six GnRH forms (t-GnRH-3-8) and four GnRH receptor subtypes (Ci-GnRHR-1-4) were identified in the protochordate, Ciona intestinalis. In this study, we show the functional modulation of Ci-GnRHR-1 via heterodimerization with the orphan receptor subtype, Ci-GnRHR-4. The dimerization between Ci-GnRHR-1 and R-4 was detected by co-immunoprecipitation and immunoblot analysis. Binding assays confirmed the binding of t-GnRHs to Ci-GnRHR-1 but not to R-4, and verified no alternation in ligand-binding affinity between Ci-GnRHR-1 homodimer and Ci-GnRHRI&4 heterodimer. The heterodimer was found to stimulate the elevation of intracellular calcium, time-extension of ERK phosphorylation, and up-regulation of cell proliferation, all in a ligand specific manner, compared with the Ci-GnRHR-1 homodimer. In combination, these results indicated that Ci-GnRHR-4 is not an inactive receptor, but a modulatory factor for Ci-GnRHR-1 in C. intestinalis.

Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis. Short communication. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis. Short communication. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta biologica Hungarica

VOLUME: 59 Suppl

Page Numbers: 241-3

Journal Abbreviation: Acta. Biol. Hung.

ISSN: 0236-5383

DAY: 25

MONTH: 07

YEAR: 2008

Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis. Short communication. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8404358

Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis. Short communication. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis. Short communication. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis. Short communication.

AFFILIATION: Suntory Institute for Bioorganic Research, Osaka, Japan. sakai@sunbor.or.jp

Country: Hungary

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Acta Biol Hung

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis Short communication Related Publications

• 4-O-Acetyl mycarose. A new O-acetyl sugar obtained from leucomycin minor components.
• A SMAP Gene Family Encoding ARF GTPase-Activating Proteins and Its Implication in Membrane Trafficking.
• A novel sphingophosphonoglycolipid containing 3-O-methylgalactose isolated from the skin of the marine gastropod Aplysia kurodai.
• ACID AND ALKALINE DEGRADATION OF THE TNP-AMINO ACIDS AND -PEPTIDES.
• An enzyme cycling method for measurement of allantoin in human serum.
• Biochemical characterization of the neuron. ATPase and acetylcholinesterase activities of neuronal cell bodies isolated in bulk from the pig brain stem.
• Characterization of phosphonoglycosphingolipids containing pyruvate: localization in Aplysia nerve bundles.
• Chemical Constituents of Morinda citrifolia Roots Exhibit Hypoglycemic Effects in Streptozotocin-Induced Diabetic Mice.
• Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1.
• Clinical management of autoimmune pancreatitis.
• Comparison of 30 immunity-related genes from the common marmoset with orthologues from human and mouse.
• Different stability of N- and C-domain of diferric ovotransferrin in urea and application to the determination of iron distribution between the two domains.
• Fluorescence Response of a 4-Trifluoroacetylaminophthalimide to Iodide Ions upon 254 nm Irradiation in MeCN.
• Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis. Short communication.
• Gangliosides in neuron.
• Glycolipids in the nervous tissue of invertebrate.
• HEMOGLOBINS FROM ERYTHROCYTES OF EEL, ANGUILLA JAPONICA.
• Heterogeneity of hemoglobin from Arca (Anadara satowi). Molecular weights and oxygen equilibria of Arca Hb I and II.
• Immunochemical and histochemical studies on a phosphonoglycosphingolipid, SGL-II, isolated from the sea gastropod Aplysia kurodai.
• Isolation and characterization of a novel 2-aminoethylphosphonyl-glycosphingolipid from the sea hare, Aplysia kurodai.
• Negative cooperativity of chicken ovotransferrin on Al(III)-binding.
• On the chemical structure of porcine globin alpha.
• On the molecular weight of hemoglobin from Anadara inflata at various pH.
• Selective modification of myosin SH1 with 1,2,4-trinitrobenzene. VIII. Thiols of myosin.
• Steady state characteristics of acclimated hydrogenotrophic methanogens on inorganic substrate in continuous chemostat reactors.
• Structural analysis of a novel triphosphonoglycosphingolipid from the egg of the sea hare, Aplysia kurodai.
• Studies on insulin. IV. On the amino acid composition of the glycyl chain of Bonito insulin-I.
• The spectrophotometric determination as trinitrophenyl derivatives of amino acids and peptides resolved on paper by electrophoresis and chromatography.
• [Calcium oxalate crystals in several kinds of Cinnamon bark]
• [Patterns of mediastinal and supraclavicular metastases in apical invasive lung cancer--importance of supraclavicular lymph node dissection]