Functioning of mitochondria-bound hexokinase in rat brain in accordance with generation of ATP inside the organelle.

Functioning of mitochondria-bound hexokinase in rat brain in accordance with generation of ATP inside the organelle. Research Abstract Details 

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Functioning of mitochondria-bound hexokinase in rat brain in accordance with generation of ATP inside the organelle. Abstract Text:

M Inui,S Ishibashi,

The function of mitochondria-bound hexokinase, the enzymatic form peculiar to the brain, in utilization of ATP generated inside the organelles, was examined by incubating rat brain mitochondrial fraction with [14C]glucose under various conditions. Addition of succinate and ADP to the incubation medium increased glucose 6-phosphate formation by the mitochondrial hexokinase and caused a smaller increase in ATP concentration in the mitochondria. The glucose phosphorylation was markedly inhibited by the addition of dinitrophenol, potassium cyanide, and oligomycin, and the ATP concentration was decreased. On the other hand, addition of atractyloside suppressed the glucose phosphorylation without affecting the mitochondrial hexokinase activity, whereas addition of antiserum against the mitochondrial hexokinase inhibited both glucose 6-phosphate formation and hexokinase activity. A part of both the glucose phosphorylation and hexokinase activities, however, remained even in the presence of the maximum dose of the anti-hexokinase serum and atractyloside. These results indicate the active utilization of intrinsically generated ATP by the mitochondria-bound hexokinase, a part of which may be located away from the surface of the mitochondrial membrane.

Functioning of mitochondria-bound hexokinase in rat brain in accordance with generation of ATP inside the organelle. Publishing Authors By Initials

M Inui,S Ishibashi,

For similar organic chemicals: carboxylic acids: acids, acyclic: dicarboxylic acids: succinic acids: succinic acid: succinates research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: dicarboxylic acids: succinic acids: succinic acid: succinates research

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Functioning of mitochondria-bound hexokinase in rat brain in accordance with generation of ATP inside the organelle. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 85

Page Numbers: 1151-6

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: May

YEAR: 1979

Functioning of mitochondria-bound hexokinase in rat brain in accordance with generation of ATP inside the organelle. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Functioning of mitochondria-bound hexokinase in rat brain in accordance with generation of ATP inside the organelle. Keywords Mesh Terms:

KEYWORDS: Succinates

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Functioning of mitochondria-bound hexokinase in rat brain in accordance with generation of ATP inside the organelle. Information

Substance Name: Hexokinase

Registry Number: EC 2.7.1.1

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Country: JAPAN

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MEDLINETA: J Biochem

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