Functionalized micellar systems for cancer targeted drug delivery.

Functionalized micellar systems for cancer targeted drug delivery. Research Abstract Details 

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Functionalized micellar systems for cancer targeted drug delivery. Abstract Text:

Damon Sutton,Norased Nasongkla,Elvin Blanco,Jinming Gao,

Polymer micelles are rapidly becoming a powerful nanomedicine platform for cancer therapeutic applications due to their small size (10-100 nm), in vivo stability, ability to solubilize water insoluble anticancer drugs, and prolonged blood circulation times. Recent data from clinical trials with three micelle formulations have highlighted these and other pharmacokinetic advantages with reduced systemic toxicity and patient morbidity compared to conventional drug formulation. While the initial anti-tumor efficacy of these systems seems promising, a strong research impetus has been placed on micelle functionalization in order to achieve tumor targeting and site-specific drug release, with the hope of reaching a more pronounced tumor response. Hence, the purpose of this review is to draw attention to the new developments of multi-functional polymer micelles for cancer therapy with special focus on tumor targeting and controlled drug release strategies.

Functionalized micellar systems for cancer targeted drug delivery. Publishing Authors By Initials

D Sutton,N Nasongkla,E Blanco,J Gao,

For similar macromolecular substances: polymers research abstracts see: macromolecular substances: polymers research

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Functionalized micellar systems for cancer targeted drug delivery. Journal Published:

PUBLICATION TYPE: Review

Journal: Pharmaceutical research

VOLUME: 24

Page Numbers: 1029-46

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 24

MONTH: 03

YEAR: 2007

Functionalized micellar systems for cancer targeted drug delivery. Information

Number of References: 129

LANGUAGE: eng

NlmUniqueID: 8406521

Functionalized micellar systems for cancer targeted drug delivery. Keywords Mesh Terms:

KEYWORDS: Polymers

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Functionalized micellar systems for cancer targeted drug delivery. Information

Substance Name: Polymers

Registry Number: 0

Grant and Affiliation Information for Functionalized micellar systems for cancer targeted drug delivery.

AFFILIATION: Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, Texas 75390, USA. jinming.gao@utsouthwestern.edu

Country: United States

AGENCY: United States NIBIB

GRANT: R21-EB-005394

ACRONYM: EB

MEDLINETA: Pharm Res

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