Functional studies of an HIV-1 encoded glutathione peroxidase.

Functional studies of an HIV-1 encoded glutathione peroxidase. Research Abstract Details 

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Functional studies of an HIV-1 encoded glutathione peroxidase. Abstract Text:

Lijun Zhao,Babatunde Olubajo,Ethan Will Taylor,

In an alternate reading frame overlapping the viral envelope gene, HIV-1 has been shown to encoded a truncated glutathione peroxidase (GPx) module. Essential active site residues of the catalytic core regions of mammalian GPx sequences are conserved in the putative viral GPx (vGPx, encoded by the env-fs gene). Cells transfected with an HIV-1 env-fs construct show up to a 100% increase in GPx enzyme activity, and are protected against the loss of mitochondrial transmembrane potential and subsequent cell death induced by exogenous oxidants or mitochondrial reactive oxygen species. An intact vGPx gene was observed to be more common in HIV-1-infected long-term non-progressors, as compared to HIV-1 isolates from patients developing AIDS. An antioxidant/antiapoptotic protective role of the vGPx is also consistent with the observation that -1 frameshifting induced by the HIV-1 env-fs sequence AAAAAGA (which contains a potential "hungry" arginine codon, AGA) increases during arginine deficiency, which has been associated with increased oxidative stress. Under arginine-limited conditions, nitric oxide synthase generates superoxide, which rapidly combines with NO to form peroxynitrite, which can cause activated T-cells to undergo apoptosis. Thus, biosynthesis of the HIV-1 GPx as an adaptive response to low arginine conditions might delay oxidant-induced apoptotic cell death, providing an enhanced opportunity for viral replication.

Functional studies of an HIV-1 encoded glutathione peroxidase. Publishing Authors By Initials

L Zhao,B Olubajo,EW Taylor,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation research

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Functional studies of an HIV-1 encoded glutathione peroxidase. Journal Published:

PUBLICATION TYPE: Review

Journal: BioFactors (Oxford, England)

VOLUME: 27

Page Numbers: 93-107

Journal Abbreviation: Biofactors

ISSN: 0951-6433

DAY: 3

MONTH: 12

YEAR: 2006

Functional studies of an HIV-1 encoded glutathione peroxidase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8807441

Functional studies of an HIV-1 encoded glutathione peroxidase. Keywords Mesh Terms:

KEYWORDS: Protein Conformation

MESH TERMS: genetics

Chemical & Substance for Abstract: Functional studies of an HIV-1 encoded glutathione peroxidase. Information

Substance Name: Glutathione Peroxidase

Registry Number: EC 1.11.1.9

Grant and Affiliation Information for Functional studies of an HIV-1 encoded glutathione peroxidase.

AFFILIATION: Office of Research and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, PO Box 26170, Greensboro, NC 27402-6170, USA.

Country: Netherlands

AGENCY: United States NIDA

GRANT: DA 13561

ACRONYM: DA

MEDLINETA: Biofactors

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