Functional roles of Otx2 transcription factor in postnatal mouse retinal development.

Functional roles of Otx2 transcription factor in postnatal mouse retinal development. Research Abstract Details 

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Functional roles of Otx2 transcription factor in postnatal mouse retinal development. Abstract Text:

Chieko Koike,Akihiro Nishida,Shinji Ueno,Hiromitsu Saito,Rikako Sanuki,Shigeru Sato,Akiko Furukawa,Shinichi Aizawa,Isao Matsuo,Noboru Suzuki,Mineo Kondo,Takahisa Furukawa,Chieko Koike,Akihiro Nishida,Shinji Ueno,Hiromitsu Saito,Rikako Sanuki,Shigeru Sato,Akiko Furukawa,Shinichi Aizawa,Isao Matsuo,Noboru Suzuki,Mineo Kondo,Takahisa Furukawa,

We previously reported that Otx2 is essential for photoreceptor cell fate determination; however, the functional role of Otx2 in postnatal retinal development is still unclear although it has been reported to be expressed in retinal bipolar cells and photoreceptors at postnatal stages. In this study, we first examined the roles of Otx2 in the terminal differentiation of photoreceptors by analyzing Otx2; Crx double-knockout mice. In Otx2+/-; Crx-/- retinas, photoreceptor degeneration and downregulation of photoreceptor-specific genes were much more prominent than in Crx-/- retinas, suggesting that Otx2 has a role in the terminal differentiation of the photoreceptors. Moreover, bipolar cells decreased in the Otx2+/-; Crx-/- retina, suggesting that Otx2 is also involved in retinal bipolar-cell development. To further investigate the role of Otx2 in bipolar-cell development, we generated a postnatal bipolar-cell-specific Otx2 conditional-knockout mouse line. Immunohistochemical analysis of this line showed that the expression of protein kinase C, a marker of mature bipolar cells, was significantly downregulated in the retina. Electroretinograms revealed that the electrophysiological function of retinal bipolar cells was impaired as a result of Otx2 ablation. These data suggest that Otx2 plays a functional role in the maturation of retinal photoreceptor and bipolar cells.

Functional roles of Otx2 transcription factor in postnatal mouse retinal development. Publishing Authors By Initials

C Koike,A Nishida,S Ueno,H Saito,R Sanuki,S Sato,A Furukawa,S Aizawa,I Matsuo,N Suzuki,M Kondo,T Furukawa,C Koike,A Nishida,S Ueno,H Saito,R Sanuki,S Sato,A Furukawa,S Aizawa,I Matsuo,N Suzuki,M Kondo,T Furukawa,

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Functional roles of Otx2 transcription factor in postnatal mouse retinal development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biology

VOLUME: 27

Page Numbers: 8318-29

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 1098-5549

DAY: 1

MONTH: 10

YEAR: 2007

Functional roles of Otx2 transcription factor in postnatal mouse retinal development. Information

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LANGUAGE: eng

NlmUniqueID: 8109087

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Grant and Affiliation Information for Functional roles of Otx2 transcription factor in postnatal mouse retinal development.

AFFILIATION: Department of Developmental Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan.

Country: United States

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MEDLINETA: Mol Cell Biol

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