Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis.

Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis. Research Abstract Details 

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Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis. Abstract Text:

Tie Li,Luo Lu,

CTCF, a nuclear transcriptional factor, is a multifunctional protein and involves regulation of growth factor- and cytokine-induced cell proliferation/differentiation. In the present study, we investigated the role of CTCF in protecting stress-induced apoptosis in various human cell types. We found that UV irradiation and hyper-osmotic stress induced human corneal epithelial (HCE) and hematopoietic myeloid cell apoptosis detected by significantly increased caspase 3 activity and decreased cell viability. The stress-induced apoptotic response in these cells requires down-regulation of CTCF at both mRNA and protein levels, suggesting that CTCF may play an important role in downstream events of stress-induced signaling pathways. Inhibition of NFkappaB activity prevented stress-induced down-regulation of CTCF and increased cell viability against stress-induced apoptosis. The anti-apoptotic effect of CTCF was further studied by manipulating CTCF activities in HCE and hematopoietic cells. Transient transfection of cDNAs encoding full-length human CTCF markedly suppressed stress-induced apoptosis in these cells. In contrast, knocking down of CTCF mRNA using siRNA specific to CTCF significantly promoted stress-induced apoptosis. Thus, our results reveal that CTCF is a down stream target of stress-induced signaling cascades and it plays a significant anti-apoptotic role in regulation of stress-induced cellular responses in HCE and hematopoietic myeloid cells.

Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis. Publishing Authors By Initials

T Li,L Lu,

For similar environment and public health: environment: meteorological factors: atmosphere: weather: sunlight: ultraviolet rays research abstracts see: environment and public health: environment: meteorological factors: atmosphere: weather: sunlight: ultraviolet rays research

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Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental cell research

VOLUME: 313

Page Numbers: 3057-65

Journal Abbreviation: Exp. Cell Res.

ISSN: 0014-4827

DAY: 24

MONTH: 05

YEAR: 2007

Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 373226

Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis. Keywords Mesh Terms:

KEYWORDS: Ultraviolet Rays

MESH TERMS: physiology

Chemical & Substance for Abstract: Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis. Information

Substance Name: Repressor Proteins

Registry Number: 0

Grant and Affiliation Information for Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis.

AFFILIATION: Department of Medicine, HMC, David Geffen School of Medicine, University of California-Los Angeles, Torrance, CA 90502, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY 15282

ACRONYM: EY

MEDLINETA: Exp Cell Res

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