Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study.

Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study. Research Abstract Details 

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Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study. Abstract Text:

C Dyon-Laurent,S Romand,A Biegon,S Sara,

Previous experiments revealed that the cholinergic deficit in rats with a partial fornix section was accompanied by an increase in turnover of noradrenaline (NE) in the hippocampus. This noradrenergic hyperactivity contributed to the cognitive deficit in lesioned rats, probably by interaction with the cholinergic system. The present experiment examines the reorganization of the noradrenergic system after the damage induced by partial fornix section and attempts to determine if the increase in NE turnover is of locus coeruleus (LC) origin, or if it is a result of local regulation at the noradrenergic terminals. Rats were submitted to knife-cut section of the fornix, resulting in a decrease in choline acetyltransferase activity in the hippocampus, correlated with a significant behavioral deficit in a spatial memory task. Lesioned rats learned a nonspatial memory task normally. Sections of brains of these rats were submitted to quantitative autoradiography. [125I]Iodopindolol binding was assessed in the dorsal and ventral hippocampus to determine availability of beta receptors. This was found to be significantly lower in lesioned rats. [125I]Iodoclonidine was used to determine alpha 2 receptors binding in dorsal and ventral hippocampus and in LC. There was no difference in alpha 2 receptors in LC, a significant decrease in dorsal regions of the hippocampus, and a significant increase in ventral regions. Muscarinic M1 receptors in the hippocampus showed no changes after the lesion.

Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study. Publishing Authors By Initials

C Dyon-Laurent,S Romand,A Biegon,S Sara,

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Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 96

Page Numbers: 203-11

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1993

Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study. Keywords Mesh Terms:

KEYWORDS: Tritium

MESH TERMS: metabolism

Chemical & Substance for Abstract: Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study. Information

Substance Name: Choline O-Acetyltransferase

Registry Number: EC 2.3.1.6

Grant and Affiliation Information for Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study.

AFFILIATION: Institut des Neurosciences, Université P & M Curie, Paris, France.

Country: GERMANY

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MEDLINETA: Exp Brain Res

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