Functional relationship between platelet alpha 2-adrenoceptors and sympathetic nerve activity in man.

Functional relationship between platelet alpha 2-adrenoceptors and sympathetic nerve activity in man. Research Abstract Details 

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Functional relationship between platelet alpha 2-adrenoceptors and sympathetic nerve activity in man. Abstract Text:

T Noshiro,Y Miura,S Kimura,Y Meguro,T Sugawara,H Ohashi,M Takahashi,N Sano,H Watanabe,T Ohzeki,

Functional relationships between platelet alpha 2-adrenoceptors and sympathetic nerve activity were studied in patients with essential hypertension (n = 23), primary aldosteronism (n = 10), and normal subjects (n = 12). The maximum number of binding sites (Bmax) and the dissociation constant (Kd) of 3H-yohimbine on platelet membranes and resting plasma norepinephrine (NE) were similar among these groups of subjects. In all subjects combined, Bmax values were correlated positively (r = 0.471, p less than 0.01) to resting plasma NE and negatively (r = -0.531, p less than 0.01) to the changes in plasma NE when subjects were moved from lying to standing. A 2-4 week treatment with guanabenz or bethanidine induced a parallel fall of both Bmax and plasma NE, whereas administration of reserpine caused a similar fall of plasma NE but Bmax remained unchanged. Kd values were not changed after any of these treatments. The results support the view that platelet alpha 2-adrenoceptor density is functionally regulated in parallel with sympathetic nerve activity rather than plasma NE per se. This hypothesis seems quite reasonable when it is extended to the presynaptic alpha 2-adrenoceptors; otherwise, the negative feedback function on NE release should be lessened and contradictory to its physiological role.

Functional relationship between platelet alpha 2-adrenoceptors and sympathetic nerve activity in man. Publishing Authors By Initials

T Noshiro,Y Miura,S Kimura,Y Meguro,T Sugawara,H Ohashi,M Takahashi,N Sano,H Watanabe,T Ohzeki,

For similar chemical actions and uses: pharmacologic actions: physiological effects of drugs: peripheral nervous system agents: autonomic agents: sympatholytics research abstracts see: chemical actions and uses: pharmacologic actions: physiological effects of drugs: peripheral nervous system agents: autonomic agents: sympatholytics research

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Functional relationship between platelet alpha 2-adrenoceptors and sympathetic nerve activity in man. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 11 Suppl 1

Page Numbers: 287-94

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1989

Functional relationship between platelet alpha 2-adrenoceptors and sympathetic nerve activity in man. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Functional relationship between platelet alpha 2-adrenoceptors and sympathetic nerve activity in man. Keywords Mesh Terms:

KEYWORDS: Sympatholytics

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Functional relationship between platelet alpha 2-adrenoceptors and sympathetic nerve activity in man. Information

Substance Name: Epinephrine

Registry Number: 51-43-4

Grant and Affiliation Information for Functional relationship between platelet alpha 2-adrenoceptors and sympathetic nerve activity in man.

AFFILIATION: Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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