Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells.

Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells. Abstract Text:

Janet Glassford,Neil Rabin,Eric W-F Lam,Kwee L Yong,Janet Glassford,Neil Rabin,Eric W-F Lam,Kwee L Yong,

D-type cyclin genes are universally dysregulated in multiple myeloma (MM), but the functional consequences are unclear as D-type cyclin gene expression does not correlate with proliferation or disease progression. We examined the protein expression and regulation of D-type cyclins and other cell cycle regulators in human myeloma cell lines and primary CD138(+) plasma cells (PCs). Cyclin D1, cyclin D2, cyclin dependent kinase (CDK) 4, CDK6, p27(Kip1) p18(INK4C) and retinoblastoma protein (pRb) were absent in normal PCs, heterogeneously expressed in primary MM cells and positively correlated with disease activity/progression. Cyclins D1 and D2 complexed with both CDK4 and CDK6, suggesting that both phosphorylate pRb in MM. Furthermore, cyclin D2 expressed via either t(14;16) or t(4;14) IgH translocations was functionally upregulated by fetal calf serum or insulin-like growth factor-I, leading to pRb phosphorylation and cell cycle entry/progression, and in some cases inversely correlated with p27(Kip1). However, pRb phosphorylation and cell cycle progression mediated by cyclin D1 expressed via t(11;14) was less dependent on exogenous stimuli. These data suggest that the presence or absence of specific IgH translocations underlying aberrant D-type cyclin expression may influence their response to mitogens in the bone marrow microenvironment. We showed for the first time that D-type cyclins are functionally regulated in MM, differentially responsive to exogenous growth factors and upregulated with disease progression.

Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells. Publishing Authors By Initials

J Glassford,N Rabin,EW Lam,KL Yong,J Glassford,N Rabin,EW Lam,KL Yong,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: British journal of haematology

VOLUME: 139

Page Numbers: 243-54

Journal Abbreviation: Br. J. Haematol.

ISSN: 0007-1048

DAY: 27

MONTH: Oct

YEAR: 2007

Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372544

Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells.

AFFILIATION: Department of Haematology, University College London, London, UK. j.glassford@ucl.ac.uk

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Br J Haematol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells Related Publications

• A Natural Polymorphism in Peroxisome Proliferator-Activated Receptor-{alpha} Hinge Region Attenuates Transcription due to Defective Release of Nuclear Receptor Corepressor from Chromatin.
• A simple and inexpensive technique of upper abdominal wall retraction in pediatric liver surgery and transplantation.
• Characteristics of a Lagrangian, high-frequency plate element for the static temperature behavior of low-frequency quartz resonators.
• Domestic arthropods and their allergens.
• Effect of iron on adherence and cytotoxicity of Entamoeba histolytica to CHO cell monolayers.
• Enhancement of solubility, dissolution and bioavailability of Ibuprofen in solid dispersion systems.
• Evaluation of Cu in hepatocellular carcinoma by particle induced X-ray emission.
• Evaluation of physicochemical properties, skin permeation and accumulation profiles of ketorolac fatty ester prodrugs.
• Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester.
• Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells.
• Further Dibenzocyclooctadiene Lignans from Roots and Stems of Kadsura longipedunculata.
• Leiomyosarcoma of the pancreas.
• MMPs in the central nervous system: Where the good guys go bad.
• Microendoscopic discectomy, a less traumatic procedure for lumbar disk herniation.
• Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium.
• Open reduction and interfragmentary screw fixation for symptomatic nonunion of distal phalangeal fractures.
• Palladium-catalyzed chemo- and enantioselective oxidation of allylic esters and carbonates.
• Partial splenectomy for benign splenic cysts with the aid of a lin clamp: technical note.
• Pelvic remodelling after the Chiari osteotomy. A long-term review.
• Polymorphic and sex-limited phosphoglucomutase in Parastrongylus cantonensis (Nematoda: Angiostrongylidae).
• Quadrapod mesh for posterior wall reconstruction in adult inguinal hernias.
• Re: Multifocal deep space hand infection secondary to haematogenous spread from chronic epididymo-orchitis.
• Sensitive and rapid method to quantify icaritin and desmethylicaritin in human serum using gas chromatography-mass spectrometry.
• Sequence polymorphisms of major German cockroach allergens Bla g 1, Bla g 2, Bla g 4, and Bla g 5.
• Sociodemographic and psychosocial correlates of smoking-induced deprivation and its effect on quitting: findings from the International Tobacco Control Policy Evaluation Survey.
• Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species.
• Three-Dimensional Finite-Element Solution of the Lagrangean Equations for the Frequency-Temperature Behavior of Y-Cut and NT-Cut Bars.
• Trace analysis of icariin in human serum with dansyl chloride derivatization after oral administration of Epimedium decoction by liquid chromatography tandem mass spectrometry.
• Visualizing the Regenerated Peripheral Nerve In vivo and In vitro.
• [A novel binary vector to get marker-free transgenic plant]