Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs).

Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Abstract Text:

Maren Krull,Mirjan Petrusma,Wojciech Makalowski, Brosius, Schmitz,

Exonization of retroposed mobile elements, a process whereby new exons are generated following changes in non-protein-coding regions of a gene, is thought to have great potential for generating proteins with novel domains. Our previous analysis of primate-specific Alu-short interspersed elements (SINEs) showed, however, that during their 60 million years of evolution, SINE exonizations occurred in some primates, only to be lost again in some of the descendent lineages. This dynamic gain and loss makes it difficult to ascertain the contribution of exonization to genomic novelty. It was speculated that Alu-SINEs are too young to reveal persistent protein exaptation. In the present study we examined older mobile elements, mammalian-wide interspersed repeats (MIRs) that underwent active retroposition prior to the placental mammalian radiation approximately 130 million years ago, to determine their contribution to protein-coding sequences. Of 107 potential cases of MIR exonizations in human, an analysis of splice sites substantiates a mechanism that benefits from 3' splice site selection in MIR sequences. We retraced in detail the evolution of five MIR elements that exonized at different times during mammalian evolution. Four of these are expressed as alternatively spliced transcripts; three in species throughout the mammalian phylogenetic tree and one solely in primates. The fifth is the first experimentally verified, constitutively expressed retroposed SINE element in mammals. This pattern of highly conserved, alternatively and constitutively spliced MIR sequences evinces the potential of exonized transposed elements to evolve beyond the transient state found in Alu-SINEs and persist as important parts of functional proteins.

Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Publishing Authors By Initials

M Krull,M Petrusma,W Makalowski,J Brosius,J Schmitz,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: dna: retroelements research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: dna: retroelements research

PUBMED ID PMID:

MEDLINE DATE:

Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genome research

VOLUME: 17

Page Numbers: 1139-45

Journal Abbreviation: Genome Res.

ISSN: 1088-9051

DAY: 10

MONTH: 07

YEAR: 2007

Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9518021

Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Keywords Mesh Terms:

KEYWORDS: Retroelements

MESH TERMS: genetics

Chemical & Substance for Abstract: Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Information

Substance Name: Retroelements

Registry Number: 0

Grant and Affiliation Information for Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs).

AFFILIATION: Institute of Experimental Pathology (ZMBE), University of Münster, Münster, Germany.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Genome Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Functional persistence of exonized mammalian-wide interspersed repeat elements MIRs Related Publications

• A Biodegradable Slotted Tube Stent Based on Poly(L: -lactide) and Poly(4-hydroxybutyrate) for Rapid Balloon-Expansion.
• Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease.
• Adding MEMS feedback to behavioral smoking cessation therapy increases compliance with bupropion: a replication and extension study.
• Adult paratesticular malignant fibrous histiocytoma treated with surgery, systemic chemotherapy and postoperative adjuvant radiotherapy.
• An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells.
• Beta-amyloid (Abeta40, Abeta42) binding to modified LDL accelerates macrophage foam cell formation.
• Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women.
• Experimental evidence for a behavior-mediated trophic cascade in a terrestrial food chain.
• Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs).
• Human Aldehyde Oxidase 1 Interacts with ATP-binding Cassette Transporter-1 and Modulates its Activity in Hepatocytes.
• Hybrid 3D Sono/PET in a mouse.
• Improved expression of kinases in Baculovirus-infected insect cells upon addition of specific kinase inhibitors to the culture helpful for structural studies.
• Infant mortality in the Federal District, Brazil: time trend and socioeconomic inequalities.
• Lipids and the progression of renal disease.
• Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells.
• Moderate resistance training and vascular health in overweight women.
• NCAM is ubiquitylated, endocytosed and recycled in neurons.
• Physicians' judgement and comprehensive geriatric assessment (CGA) select different patients as fit for chemotherapy.
• Predator diversity and trophic interactions.
• Removal forces and adhesion properties of Saccharomyces cerevisiae on glass substrates probed by optical tweezer.
• Retroposed elements and their flanking regions resolve the evolutionary history of xenarthran mammals (armadillos, anteaters, and sloths).
• Safety of Strength Training in Women: Musculoskeletal Injuries in the Strong, Healthy, and Empowered Study: 2179: Board #92 June 1 8:00 AM -9:30 AM.
• The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro.
• The association of physical activity with lung cancer incidence in a cohort of older women: the Iowa Women's Health Study.
• The bootstrap and cross-validation in neuroimaging applications: estimation of the distribution of extrema of random fields for single volume tests, with an application to ADC maps.
• The role of drug use outcome expectancies in substance abuse risk: an interactional-transformational model.
• Ultrasonic bubbles in medicine: Influence of the shell.
• Using addiction severity profiles to differentiate cocaine-dependent patients with and without comorbid major depression.
• Volume, neuron density and total neuron number in five subcortical regions in schizophrenia.
• [Twelve years of the Baby-Friendly Hospital Initiative in Brazil]