Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow.

Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow. Abstract Text:

Ming-Song Tsai,Shiaw-Min Hwang,Kuang-Den Chen,Yun-Shien Lee,Li-Wen Hsu,Yu-Jen Chang,Chao-Nin Wang,Hsiu-Huei Peng,Yao-Lung Chang,An-Shine Chao,Shuenn-Dyh Chang,Kuan-Der Lee,Tzu-Hao Wang,Hsin-Shih Wang,Yung-Kuei Soong,Ming-Song Tsai,Shiaw-Min Hwang,Kuang-Den Chen,Yun-Shien Lee,Li-Wen Hsu,Yu-Jen Chang,Chao-Nin Wang,Hsiu-Huei Peng,Yao-Lung Chang,An-Shine Chao,Shuenn-Dyh Chang,Kuan-Der Lee,Tzu-Hao Wang,Hsin-Shih Wang,Yung-Kuei Soong,Ming-Song Tsai,Shiaw-Min Hwang,Kuang-Den Chen,Yun-Shien Lee,Li-Wen Hsu,Yu-Jen Chang,Chao-Nin Wang,Hsiu-Huei Peng,Yao-Lung Chang,An-Shine Chao,Shuenn-Dyh Chang,Kuan-Der Lee,Tzu-Hao Wang,Hsin-Shih Wang,Yung-Kuei Soong,

Using high-density oligonucleotide microarrays and functional network analyses, we examined whether MSCs derived from four different origins exhibited unique gene expression profiles individually and then compared the gene expression profiles of all MSCs with those of fetal organs. Our results indicated that within each group of MSCs from the same origin, the variability of the gene expression levels was smaller than that between groups of different origins. Functional genomic studies revealed the specific roles of MSCs from different origins. Our results suggest that amniotic fluid MSCs may initiate interactions with the uterus by upregulating oxytocin and thrombin receptors. Amniotic membrane MSCs may play a role in maintaining homeostasis of fluid and electrolytes by regulating the networks of endothelin, neprilysin, bradykinin receptors, and atrial natriuretic peptide. Cord blood MSCs may be involved in innate immune systems as the neonatal defense system against the earliest encountered pathogens. Adult bone marrow MSCs may be an important source not only of all blood lineages but also of bone formation. However, in spite of the different gene expression profiles seen in MSCs derived from different origins, a set of core gene expression profiles was preserved in these four kinds of MSCs. The core signature transcriptomes of all MSCs, when contrasted against those of fetal organs, included genes involved in the regulation of extracellular matrix and adhesion, transforming growth factor-beta receptor signaling, and the Wnt signaling pathways. Disclosure of potential conflicts of interest is found at the end of this article.

Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow. Publishing Authors By Initials

MS Tsai,SM Hwang,KD Chen,YS Lee,LW Hsu,YJ Chang,CN Wang,HH Peng,YL Chang,AS Chao,SD Chang,KD Lee,TH Wang,HS Wang,YK Soong,MS Tsai,SM Hwang,KD Chen,YS Lee,LW Hsu,YJ Chang,CN Wang,HH Peng,YL Chang,AS Chao,SD Chang,KD Lee,TH Wang,HS Wang,YK Soong,MS Tsai,SM Hwang,KD Chen,YS Lee,LW Hsu,YJ Chang,CN Wang,HH Peng,YL Chang,AS Chao,SD Chang,KD Lee,TH Wang,HS Wang,YK Soong,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Stem cells (Dayton, Ohio)

VOLUME: 25

Page Numbers: 2511-23

Journal Abbreviation: Stem Cells

ISSN: 1549-4918

DAY: 7

MONTH: 06

YEAR: 2007

Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9304532

Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow.

AFFILIATION: Prenatal Diagnosis Center, Cathay General Hospital, Taipei, Taiwan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Stem Cells

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow Related Publications

• A Smooth Muscle Cav1.2 Calcium Channel Splice Variant Underlies Hyperpolarized Window Current and Enhanced State-dependent Inhibition by Nifedipine.
• A four-parameter logistic model for estimating titers of functional multiplexed pneumococcal opsonophagocytic killing assay.
• A two-stage binomial test approach of gene identification in oligonucleotide arrays.
• Angioplasty through aortofemoral graft: use of catheter-introducer sheath.
• Clonal Characterization of Sporadic Cribriform-Morular Variant of Papillary Thyroid Carcinoma by Laser Microdissection-Based APC Mutation Analysis.
• Differential splicing patterns of L-Type calcium channel Ca(v)1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto rats.
• Effects Of Chinese Style Exercise On RRPmax, METSmax And Body Composition In Sedentary Chinese: 1571: Board #61 May 30 3:30 PM - 5:00 PM.
• Effects of CXCL10 on dendritic cell and CD4+ T-cell functions during Leishmania amazonensis infection.
• Endoscopic intubation with aid of mechanical ventilation via a dedicated nasopharyngeal airway.
• Establishing a liquid-phase IEF in combination with 2-DE for the analysis of Leishmania proteins.
• Free microvascular transfer of the vermiform appendix and colon for creation of a uterovaginal fistula: a new technique for cervicovaginal reconstruction.
• Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow.
• Identification and enzymatic activities of four protein disulfide isomerase (PDI) isoforms of Leishmania amazonensis.
• Inadvertent superovulation and intrauterine insemination during pregnancy: a lesson from an ectopic gestation.
• L-arginine and cationic amino acid transporter 2B regulate growth and survival of Leishmania amazonensis amastigotes in macrophages.
• Leishmania amastigote target antigens: the challenge of a stealthy intracellular parasite.
• Leishmania mexicana infection of the eyelid in a traveler to Belize.
• Leishmania mexicana infection of the eyelid in a traveler to Belize.
• MPZ mutation G123S characterization: Evidence for a complex pathogenesis in CMT disease.
• No difference in medium-term outcome between zenith and talent stent-grafts in endovascular aneurysm repair.
• Percutaneous cholecystostomy.
• Predicting outcomes in metastatic melanoma.
• Prediction of pregnancy rate of in vitro fertilization and embryo transfer in women aged 40 and over with basal uterine artery pulsatility index.
• Regional patterns of cerebral glucose metabolism in spinocerebellar ataxia type 2, 3 and 6 : a voxel-based FDG-positron emission tomography analysis.
• Resumption of meiosis-I tissue to enucleated preovulatory oocytes: a preliminary report.
• Role of endovenous laser treatment in the management of chronic venous insufficiency.
• Selective fetocide reversed mirror syndrome in a dichorionic triplet pregnancy with severe twin-twin transfusion syndrome: a case report.
• Sonographic prediction of significant intertwin birth weight discordance.
• The relationship of pronuclear stage morphology and chromosome status at cleavage stage.
• Topographic brain mapping of the international cooperative ataxia rating scale. A positron emission tomography study.