Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal.

Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal. Abstract Text:

Marla B Bruns,Michael W Miller,

The hypothesis tested is that cortical neurotrophins communicate through an inducible autocrine/paracrine mechanism. As ethanol (Et) can induce cortical nerve growth factor (NGF) expression, adult rats were challenged with Et on three consecutive days per week for 6 weeks. The focus of the study was layer V, the chief repository of receptor-expressing neuronal cell bodies. Brains were collected immediately after the sixth Et exposure or 72 h later [i.e., following withdrawal (WD)]. Double-label in situ hybridization-immunohistochemistry studies showed that many neuronal somata co-expressed NGF mRNA with NGF, trkA, or phosphorylated trk (p-trk), essential components of an inducible autocrine system. The frequencies of co-labeling were affected by neither Et nor WD. On the contrary, Et increased the number of NGF mRNA-expressing neurons and the amount of NGF mRNA expressed per cell. Et also increased total cortical concentration of NGF protein, the number of layer V neurons expressing trkA transcript, the amount of trkA mRNA expressed per neuron, and trkA phosphorylation. Following WD, the frequency of NGF-mRNA-expressing cells increased, although transcript and protein content fell. WD induced an increase in trkA mRNA and protein expression, however, p-trk expression was unaffected. Thus, Et treatment reveals that layer V has inducible autocrine/paracrine and anterograde neurotrophin systems. WD unveils the dynamism and recruitability of these systems.

Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal. Publishing Authors By Initials

MB Bruns,MW Miller,

For similar disorders of environmental origin: substance-related disorders: substance withdrawal syndrome research abstracts see: disorders of environmental origin: substance-related disorders: substance withdrawal syndrome research

PUBMED ID PMID:

MEDLINE DATE:

Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neurochemistry

VOLUME: 100

Page Numbers: 1155-68

Journal Abbreviation: J. Neurochem.

ISSN: 0022-3042

DAY: 3

MONTH: Mar

YEAR: 2007

Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985190

Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal. Keywords Mesh Terms:

KEYWORDS: Substance Withdrawal Syndrome

MESH TERMS: metabolism

Chemical & Substance for Abstract: Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal. Information

Substance Name: Receptor, trkA

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal.

AFFILIATION: Department of Neuroscience and Physiology, State University of New York-Upstate Medical University, Syracuse, New York 13210, USA.

Country: England

AGENCY: United States NIAAA

GRANT: AA15245

ACRONYM: AA

MEDLINETA: J Neurochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal Related Publications

• Bone morphogenetic protein-2 (BMP-2) and transforming growth factor-beta1 (TGF-beta1) alter connexin 43 phosphorylation in MC3T3-E1 Cells.
• Bovine abortion and neonatal death associated with Ureaplasma diversum.
• Characterization of growth and osteogenic differentiation of rabbit bone marrow stromal cells.
• Clinical evaluation of respiratory function in newborn infants.
• Conducting research: practical steps.
• Embryo transfer techniques in handling repeat breeding cows.
• Examining the effects of alcoholism typology and AA attendance on self-efficacy as a mechanism of change.
• Fibroblast growth factor receptor-1 interacts with the T-cell receptor signalling pathway.
• HIV testing among young adults in the United States: associations with financial resources and geography.
• Importance of diet of dam and colostrum to the biological antioxidant status and parenteral iron tolerance of the pig.
• Magnetic resonance imaging of microvascular leakage induced by myocardial contrast echocardiography in rats.
• Measurements of the anisotropy of ultrasonic attenuation in freshly excised myocardium.
• Measuring the quality of medication administration.
• Overexpression of BMP-2 modulates morphology, growth, and gene expression in osteoblastic cells.
• Personal perspectives: an interview with William R. Miller.
• Prediction of fertility of bovine semen: Preliminary studies with the hamster egg penetration test.
• Predictors of unsafe injecting drug use.
• Relationship of sialic acid and fatty acid composition of brain gangliosides: breast-fed vs formula-fed infant.
• Requirement for a localized, IP3R-generated Ca2+ transient during the furrow positioning process in zebrafish zygotes.
• Serial passage of MC3T3-E1 cells alters osteoblastic function and responsiveness to transforming growth factor-beta1 and bone morphogenetic protein-2.
• Spirituality: the silent dimension in addiction research. The 1990 leonard ball oration.
• Streamlined synthesis of phosphatidylinositol (PI), PI3P, PI3,5P2, and deoxygenated analogues as potential biological probes.
• Structure and measurement of dimensions of risk for HIV transmission in injecting drug users.
• Substrate-dependent dihydroxylation of substituted cyclopentenes: toward the syntheses of carbocyclic sinefungin and noraristeromycin.
• Survival of equine embryos co-cultured with equine oviductal epithelium from the four- to eight-cell to the blastocyst stage after transfer to synchronous recipient mares.
• The electrocardiogram in congenital malformations of the heart.
• Topical hyperbaric oxygen and low-energy laser for the treatment of chronic ulcers.
• Transient expression of apoaequorin in zebrafish embryos: extending the ability to image calcium transients during later stages of development.
• Trials of vinorelbine and docetaxel in the treatment of advanced non small-cell lung cancer.
• Ultrastructural assessment of a blastocyst recovered from a cow with subclinical purulent endometritis.