Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation.

Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation. Research Abstract Details 

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Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation. Abstract Text:

Ankur M Patel,Lisa D Cahill,Jennifer Ret,Vincent Schmithorst,Daniel Choo,Scott Holland,

OBJECTIVE: To investigate functional magnetic resonance imaging (fMRI) in pediatric cochlear implantation candidates with residual hearing who are under sedation for evaluation of auditory function. DESIGN: During fMRI, subjects heard a random sequence of tones (250-4000 Hz) presented 10 dB above hearing thresholds. Tones were interleaved with silence in a block-periodic fMRI design with 30-second on-off intervals. Twenty-four axial sections (5 mm thick) covering most of the brain were obtained every 3 seconds for a total acquisition time of 5.5 minutes. SETTING: Single tertiary academic medical institution. PATIENTS: Severely to profoundly hearing-impaired children (n=10; mean age, 49.1 months). During fMRI, subjects were awake (n=2) or sedated with pentobarbital sodium if their weight was 10 kg or greater (n=4) or chloral hydrate if their weight was less than 10 kg (n=4). MAIN OUTCOME MEASURES: Detection of brain activation by fMRI in the primary auditory cortex (A1) in hearing-impaired patients under sedation, and correlation of A1 activation with hearing levels measured after cochlear implantation. RESULTS: In most subjects, fMRI detected significant levels of activation in the A1 region before cochlear implantation. The improvement in hearing threshold after cochlear implantation correlated strongly (linear regression coefficient, R=0.88) with the amount of activation in the A1 region detected by fMRI before cochlear implantation. CONCLUSIONS: Functional MRI can be considered a means of assessing residual function in the A1 region in sedated hearing-impaired toddlers. With improvements in acquisition, processing, and sedation methods, fMRI may be translated into a prognostic indicator for outcome after cochlear implantation in infants.

Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation. Publishing Authors By Initials

AM Patel,LD Cahill,J Ret,V Schmithorst,D Choo,S Holland,

For similar therapeutics: patient care: preoperative care research abstracts see: therapeutics: patient care: preoperative care research

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Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Archives of otolaryngology--head & neck surgery

VOLUME: 133

Page Numbers: 677-83

Journal Abbreviation: Arch. Otolaryngol. Head Neck S

ISSN: 0886-4470

DAY: 3

MONTH: Jul

YEAR: 2007

Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8603209

Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation. Keywords Mesh Terms:

KEYWORDS: Preoperative Care

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation. Information

Substance Name: Pentobarbital

Registry Number: 76-74-4

Grant and Affiliation Information for Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation.

AFFILIATION: Imaging Research Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA.

Country: United States

AGENCY: United States NIDCD

GRANT: R21-DC05311

ACRONYM: DC

MEDLINETA: Arch Otolaryngol Head Neck Sur

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