Functional magnetic resonance imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults.

Functional magnetic resonance imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults. Research Abstract Details 

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Functional magnetic resonance imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults. Abstract Text:

Francesca M Filbey,Kelly J Slack,Trey P Sunderland,Robert M Cohen,

Functional neural alterations are present in middle-aged to late-aged healthy individuals carrying the epsilon4 allele of the apolipoprotein E (APOEepsilon4) gene, a known risk factor for Alzheimer's disease. Neural activity was measured in young adults with and without the epsilon4 allele (APOEepsilon4+ and APOEepsilon4-) by functional magnetic resonance imaging and magnetoencephalography while performing a visual working memory task on two separate days. Greater activity was observed in frontal areas and cingulate gyri in APOEepsilon4+ participants by both functional magnetic resonance imaging and magnetoencephalography with regional blood oxygenation level-dependent responses correlating with increased theta band power. The findings suggest that the presence of the APOEepsilon4 allele has physiological consequences before aging that may contribute to risk for Alzheimer's disease.

Functional magnetic resonance imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults. Publishing Authors By Initials

FM Filbey,KJ Slack,TP Sunderland,RM Cohen,

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Functional magnetic resonance imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroreport

VOLUME: 17

Page Numbers: 1585-90

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ISSN: 0959-4965

DAY: 23

MONTH: Oct

YEAR: 2006

Functional magnetic resonance imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

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Grant and Affiliation Information for Functional magnetic resonance imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults.

AFFILIATION: Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA. Francesca.Filbey@colorado.edu

Country: England

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MEDLINETA: Neuroreport

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