Functional interactions in brain networks underlying epileptic seizures in bilateral diffuse periventricular heterotopia.

Functional interactions in brain networks underlying epileptic seizures in bilateral diffuse periventricular heterotopia. Research Abstract Details 

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Functional interactions in brain networks underlying epileptic seizures in bilateral diffuse periventricular heterotopia. Abstract Text:

Luc Valton,Maxime Guye,Aileen McGonigal,Patrick Marquis,Fabrice Wendling,Jean ,Patrick Chauvel,Fabrice Bartolomei,

OBJECTIVE: Our aim was to investigate relationships between heterotopic and remote cortical structures at seizure initiation, in a patient with bilateral periventricular nodular heterotopias (BPNH) explored by intracerebral electrodes. METHODS: Stereoelectroencephalography (SEEG) was performed in a man with BPNH and refractory epilepsy to investigate the hypothesis of right temporal lobe epilepsy and the possible involvement of heterotopic structures during seizures. SEEG signals were analyzed with quantification of functional coupling between different brain structures during seizures, using nonlinear regression. We have used Z-score transformation of correlation values to reflect the change from the preictal period. Relationships between BPNH and cortical structures were investigated using analysis of stimulation-induced potentials. RESULTS: Three spontaneous seizures were recorded and analyzed. Signal analysis of interdependencies in two seizures demonstrated a large initial network involving both heterotopia and cortical structures. Stimulations of heterotopia induced responses in remote cortical structures. CONCLUSIONS: Distinct epileptogenic networks were identified, in which leader structures were either the heterotopic or the mesial temporal structures, with functional connections between heterotopic and cortical areas. SIGNIFICANCE: These results confirm that a vast epileptogenic network, including heterotopic and cortical neurons, may be responsible for seizure generation in BPNH. This may explain certain surgical failures in this group.

Functional interactions in brain networks underlying epileptic seizures in bilateral diffuse periventricular heterotopia. Publishing Authors By Initials

L Valton,M Guye,A McGonigal,P Marquis,F Wendling,J ,P Chauvel,F Bartolomei,

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Functional interactions in brain networks underlying epileptic seizures in bilateral diffuse periventricular heterotopia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical neurophysiology : official journal of the

VOLUME: 119

Page Numbers: 212-23

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ISSN: 1388-2457

DAY: 26

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 100883319

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AFFILIATION: CHU Timone, Service de Neurophysiologie Clinique, 264 Rue St Pierre, 13005 Marseille, France; INSERM, U751, Laboratoire de Neurophysiologie et Neuropsychologie, Marseille, France; Université de la Méditerranée, Faculté de Médecine, Marseille, France.

Country: Netherlands

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MEDLINETA: Clin Neurophysiol

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