Functional insights from structural genomics.

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Functional insights from structural genomics. Abstract Text:

Farhad Forouhar,Alexandre Kuzin,Jayaraman Seetharaman,Insun Lee,Weihong Zhou,Mariam Abashidze,Yang Chen,Wei Yong,Haleema Janjua,Yingyi Fang,Dongyan Wang,Kellie Cunningham,Rong Xiao,Thomas B Acton,Eran Pichersky,Daniel F Klessig,Carl W Porter,Gaetano T Montelione,Liang Tong,Farhad Forouhar,Alexandre Kuzin,Jayaraman Seetharaman,Insun Lee,Weihong Zhou,Mariam Abashidze,Yang Chen,Wei Yong,Haleema Janjua,Yingyi Fang,Dongyan Wang,Kellie Cunningham,Rong Xiao,Thomas B Acton,Eran Pichersky,Daniel F Klessig,Carl W Porter,Gaetano T Montelione,Liang Tong,

Structural genomics efforts have produced structural information, either directly or by modeling, for thousands of proteins over the past few years. While many of these proteins have known functions, a large percentage of them have not been characterized at the functional level. The structural information has provided valuable functional insights on some of these proteins, through careful structural analyses, serendipity, and structure-guided functional screening. Some of the success stories based on structures solved at the Northeast Structural Genomics Consortium (NESG) are reported here. These include a novel methyl salicylate esterase with important role in plant innate immunity, a novel RNA methyltransferase (H. influenzae yggJ (HI0303)), a novel spermidine/spermine N-acetyltransferase (B. subtilis PaiA), a novel methyltransferase or AdoMet binding protein (A. fulgidus AF_0241), an ATP:cob(I)alamin adenosyltransferase (B. subtilis YvqK), a novel carboxysome pore (E. coli EutN), a proline racemase homolog with a disrupted active site (B. melitensis BME11586), an FMN-dependent enzyme (S. pneumoniae SP_1951), and a 12-stranded beta-barrel with a novel fold (V. parahaemolyticus VPA1032).

Functional insights from structural genomics. Publishing Authors By Initials

F Forouhar,A Kuzin,J Seetharaman,I Lee,W Zhou,M Abashidze,Y Chen,W Yong,H Janjua,Y Fang,D Wang,K Cunningham,R Xiao,TB Acton,E Pichersky,DF Klessig,CW Porter,GT Montelione,L Tong,F Forouhar,A Kuzin,J Seetharaman,I Lee,W Zhou,M Abashidze,Y Chen,W Yong,H Janjua,Y Fang,D Wang,K Cunningham,R Xiao,TB Acton,E Pichersky,DF Klessig,CW Porter,GT Montelione,L Tong,

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Functional insights from structural genomics. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of structural and functional genomics

VOLUME: 8

Page Numbers: 37-44

Journal Abbreviation: J. Struct. Funct. Genomics

ISSN: 1345-711X

DAY: 23

MONTH: 06

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 101128185

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Grant and Affiliation Information for Functional insights from structural genomics.

AFFILIATION: Department of Biological Sciences, Northeast Structural Genomics Consortium, Columbia University, New York, NY, 10027, USA, ltong@columbia.edu.

Country: Netherlands

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MEDLINETA: J Struct Funct Genomics

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