Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer.

Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer. Research Abstract Details 

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Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer. Abstract Text:

Virna Dapi?,Alvaro N A Monteiro,

The tumor suppressor gene BRCA1 was positionally cloned in 1994. During the last 12 years, several lines of evidence have implicated BRCA1 in the maintenance of genome integrity, regulation of transcriptionn, and chromatin remodeling, suggesting that it has multiple biological roles. Germline mutations in BRCA1 confer a 56%-80% lifetime risk for breast cancer and a 15%-60% lifetime risk for ovarian cancer in women. And preliminary evidence suggests that BRCA1-linked breast and ovarian tumors behave differently from sporadic tumors, justifying a tailored approach to these cancers. Although several gaps still remain in our knowledge, it is possible to use information from basic research to illuminate clinical decisions and improve the prospects of mutation carriers. Along similar lines, genetic data derived from the clinical setting are also instrumental in determining which biochemical functions of BRCA1 contribute to its tumor suppressor actions. In this article, we explore the functional implications of BRCA1 for genetic testing (early detection), prevention, and therapy.

Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer. Publishing Authors By Initials

V Dapi?,AN Monteiro,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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MEDLINE DATE:

Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Critical reviews in eukaryotic gene expression

VOLUME: 16

Page Numbers: 233-52

Journal Abbreviation: Crit. Rev. Eukaryot. Gene Expr

ISSN: 1045-4403

DAY: 3

MONTH: 12

YEAR: 2006

Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007261

Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: therapy

Chemical & Substance for Abstract: Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer. Information

Substance Name: BRCA1 Protein

Registry Number: 0

Grant and Affiliation Information for Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer.

AFFILIATION: Risk Assessment, Detection and Intervention Program, H Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA92309

ACRONYM: CA

MEDLINETA: Crit Rev Eukaryot Gene Expr

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