Functional imaging of working memory in Parkinson's disease: compensations and deficits.

Functional imaging of working memory in Parkinson's disease: compensations and deficits. Research Abstract Details 

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Functional imaging of working memory in Parkinson's disease: compensations and deficits. Abstract Text:

Rose-Marie ,Catherine Lozza,Chantal Chavoix,Gilles Louis Defer,Jean-Claude Baron,

BACKGROUND AND PURPOSE: Over and above typical motor alterations, executive and working memory (WM) impairment can also occur in early idiopathic Parkinson's disease (PD). We aimed to investigate the compensatory neural processes involved in WM performance, as well as the networks involved in the long-term memory transfer from short-term stores in PD. METHODS: Relative cerebral blood flow (rCBF) was mapped with H2O(15)-PET in eight treated nondemented PD patients while performing a WM verbal double-task (Brown-Peterson paradigm) using both short (6-second) and long (18-second) delays. RESULTS: As compared to nine age-matched healthy subjects, performance of the PD group was only slightly reduced on the short-delay but markedly impaired on the long-delay task. Underlying the relatively preserved short-delay performance, the PD group exhibited overactivation of prefrontal and parietal areas involved in attention-demanding processes, suggestive of efficient compensatory processes. Further supporting this, significant positive correlations were found between short-delay performance and rCBF in the bilateral inferior parietal cortex. In contrast, the lack of overactivation with the long-delay task together with posterior cingulate hypoactivation would support the idea of functional disconnection impairing transfer of information from prefrontal onto (para)limbic areas. These findings suggest novel areas of investigation into early cognitive impairments in PD.

Functional imaging of working memory in Parkinson's disease: compensations and deficits. Publishing Authors By Initials

RM ,C Lozza,C Chavoix,GL Defer,JC Baron,

For similar tomography, emission-computed research abstracts see: tomography, emission-computed research

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Functional imaging of working memory in Parkinson's disease: compensations and deficits. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroimaging : official journal of the

VOLUME: 17

Page Numbers: 277-85

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ISSN: 1051-2284

DAY: 20

MONTH: Oct

YEAR: 2007

Functional imaging of working memory in Parkinson's disease: compensations and deficits. Information

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LANGUAGE: eng

NlmUniqueID: 9102705

Functional imaging of working memory in Parkinson's disease: compensations and deficits. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed

MESH TERMS: methods

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Grant and Affiliation Information for Functional imaging of working memory in Parkinson's disease: compensations and deficits.

AFFILIATION: University of Caen, University Team Executive and Attentional Processes and UPRES-EA 3917, Caen, France.

Country: United States

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MEDLINETA: J Neuroimaging

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