Functional imaging of sequence learning in Parkinson's disease.

Functional imaging of sequence learning in Parkinson's disease. Research Abstract Details 

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Functional imaging of sequence learning in Parkinson's disease. Abstract Text:

Maren Carbon,David Eidelberg,

Sequence learning, a cognitive task linked to cortico-striatal function, is impaired in Parkinson's disease (PD). We chose this task as a behavioral paradigm to study the functional architecture of PD in treated and untreated conditions. In our studies, participants were scanned with H(2)(15)O while performing a kinematically controlled motor sequence learning task and a matching motor baseline task. Experiments revealed that a specific sequence learning network predicts learning in normal subjects, and in independent cohorts of early and advanced PD patients. The analysis of the relationship of network activity to learning performance revealed diverging influences of dopaminergic therapy and deep brain stimulation (DBS). DBS of the internal GP and of STN increased network activity and task performance, while levodopa decreased both measures. In separate studies, we investigated the role of dopaminergic modulation on brain activation during sequence learning. In healthy subjects dopamine transporter (DAT) binding correlated with learning-related brain activation in prefrontal, premotor and cingulate cortices, and in the thalamus. By contrast, in PD most of these regional relationships were lost. Only ventral and dorsolateral prefrontal cortex activation correlated with caudate dopaminergic input. In a final set of studies, we found a significant decline in learning performance in early stage PD patients followed over the course of 2 years. Longitudinal declines in learning-related activation were found in parietal areas, while concomitant increases were localized to the left hippocampus. These observations support hypotheses on disease-stage and task-specific effects within the different cortico-striato-pallido-thalamocortical loops and the mesocortical system in PD.

Functional imaging of sequence learning in Parkinson's disease. Publishing Authors By Initials

M Carbon,D Eidelberg,

For similar tomography, emission-computed: positron-emission tomography research abstracts see: tomography, emission-computed: positron-emission tomography research

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Functional imaging of sequence learning in Parkinson's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the neurological sciences

VOLUME: 248

Page Numbers: 72-7

Journal Abbreviation: J. Neurol. Sci.

ISSN: 0022-510X

DAY: 5

MONTH: 06

YEAR: 2006

Functional imaging of sequence learning in Parkinson's disease. Information

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LANGUAGE: eng

NlmUniqueID: 375403

Functional imaging of sequence learning in Parkinson's disease. Keywords Mesh Terms:

KEYWORDS: Positron-Emission Tomography

MESH TERMS: therapy

Chemical & Substance for Abstract: Functional imaging of sequence learning in Parkinson's disease. Information

Substance Name: Oxygen Radioisotopes

Registry Number: 0

Grant and Affiliation Information for Functional imaging of sequence learning in Parkinson's disease.

AFFILIATION: Center for Neurosciences, Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA. mcarbon@nshs.edu

Country: Netherlands

AGENCY: United States NINDS

GRANT: R01 NS 35069

ACRONYM: NS

MEDLINETA: J Neurol Sci

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