Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease.

Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease. Research Abstract Details 

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Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease. Abstract Text:

Yilong Ma,David Eidelberg,

Brain imaging of cerebral blood flow and glucose metabolism has been playing key roles in describing pathophysiology of Parkinson's disease (PD) and Huntington's disease (HD), respectively. Many biomarkers have been developed in recent years to investigate the abnormality in molecular substrate, track the time course of disease progression, and evaluate the efficacy of novel experimental therapeutics. A growing body of literature has emerged on neurobiology of these two movement disorders in resting states and in response to brain activation tasks. In this paper, we review the latest applications of these approaches in patients and normal volunteers at rest conditions. The discussions focus on brain mapping studies with univariate and multivariate statistical analyses on a voxel basis. In particular, we present data to validate the reproducibility and reliability of unique spatial covariance patterns related with PD and HD.

Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease. Publishing Authors By Initials

Y Ma,D Eidelberg,

For similar nervous system diseases: central nervous system diseases: brain diseases: basal ganglia diseases: parkinsonian disorders: parkinson disease research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: basal ganglia diseases: parkinsonian disorders: parkinson disease research

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MEDLINE DATE:

Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Molecular imaging and biology : MIB : the official

VOLUME: 9

Page Numbers: 223-33

Journal Abbreviation:

ISSN: 1536-1632

DAY: 3

MONTH: 12

YEAR: 2007

Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease. Information

Number of References: 88

LANGUAGE: eng

NlmUniqueID: 101125610

Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease. Keywords Mesh Terms:

KEYWORDS: Parkinson Disease

MESH TERMS: pathology

Chemical & Substance for Abstract: Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease. Information

Substance Name: Glucose

Registry Number: 50-99-7

Grant and Affiliation Information for Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease.

AFFILIATION: Center for Neurosciences, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, New York University School of Medicine, Manhasset, NY, USA. yma@nshs.edu

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS 37564

ACRONYM: NS

MEDLINETA: Mol Imaging Biol

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