Functional disturbances of the sympathetic nerve in experimentally-induced nasal hypersensitivity.

Functional disturbances of the sympathetic nerve in experimentally-induced nasal hypersensitivity. Research Abstract Details 

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Functional disturbances of the sympathetic nerve in experimentally-induced nasal hypersensitivity. Abstract Text:

N Kubo,T Ishibe,H Tsuji,K Kozuki,T Yamashita,T Kumazawa,

Norepinephrine, alpha-1 and beta adrenergic receptors in the nasal mucosa of toluene-diisocyanate sensitized guinea-pigs were evaluated quantitatively at specific points in time during a pre-determined sensitization period. At 4, 8 and 12 weeks, the norepinephrine content was reduced. The concentration of alpha-1 adrenergic receptors significantly decreased in 8- and 12-week groups. A lower density of beta adrenergic receptors was shown in the 12-week group. Signs of a return to normalcy were observed by four weeks post-sensitization. These results led us to speculate that excess norepinephrine release, which may be promoted by allergy-inducing histamine, depleted the norepinephrine at the sympathetic nerve terminal and caused a lowering of the concentration of sympathetic receptors. Functional disturbance of the sympathetic nerve was suggested by clinical findings of nonspecific nasal hypersensitivity, congestion and nasal discharge.

Functional disturbances of the sympathetic nerve in experimentally-induced nasal hypersensitivity. Publishing Authors By Initials

N Kubo,T Ishibe,H Tsuji,K Kozuki,T Yamashita,T Kumazawa,

For similar organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: benzene derivatives: toluene: toluene 2,4-diisocyanate research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: benzene derivatives: toluene: toluene 2,4-diisocyanate research

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Functional disturbances of the sympathetic nerve in experimentally-induced nasal hypersensitivity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 463

Page Numbers: 5-13

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1989

Functional disturbances of the sympathetic nerve in experimentally-induced nasal hypersensitivity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370355

Functional disturbances of the sympathetic nerve in experimentally-induced nasal hypersensitivity. Keywords Mesh Terms:

KEYWORDS: Toluene 2,4-Diisocyanate

MESH TERMS: metabolism

Chemical & Substance for Abstract: Functional disturbances of the sympathetic nerve in experimentally-induced nasal hypersensitivity. Information

Substance Name: Toluene 2,4-Diisocyanate

Registry Number: 584-84-9

Grant and Affiliation Information for Functional disturbances of the sympathetic nerve in experimentally-induced nasal hypersensitivity.

AFFILIATION: Department of Otolaryngology, Kansai Medical University, Osaka, Japan.

Country: SWEDEN

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MEDLINETA: Acta Otolaryngol Suppl

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