Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants.

Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants. Research Abstract Details 

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Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants. Abstract Text:

Samuel A Danziger,S Joshua Swamidass,Jue Zeng,Lawrence R Dearth,Qiang Lu,Jonathan H Chen,Jianlin Cheng,Vinh P Hoang,Hiroto Saigo,Ray Luo,Pierre Baldi,Rainer K Brachmann,Richard H Lathrop,

Many biomedical problems relate to mutant functional properties across a sequence space of interest, e.g., flu, cancer, and HIV. Detailed knowledge of mutant properties and function improves medical treatment and prevention. A functional census of p53 cancer rescue mutants would aid the search for cancer treatments from p53 mutant rescue. We devised a general methodology for conducting a functional census of a mutation sequence space by choosing informative mutants early. The methodology was tested in a double-blind predictive test on the functional rescue property of 71 novel putative p53 cancer rescue mutants iteratively predicted in sets of three (24 iterations). The first double-blind 15-point moving accuracy was 47 percent and the last was 86 percent; r = 0.01 before an epiphanic 16th iteration and r = 0.92 afterward. Useful mutants were chosen early (overall r = 0.80). Code and data are freely available (http://www.igb.uci.edu/research/research.html, corresponding authors: R.H.L. for computation and R.K.B. for biology).

Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants. Publishing Authors By Initials

SA Danziger,SJ Swamidass,J Zeng,LR Dearth,Q Lu,JH Chen,J Cheng,VP Hoang,H Saigo,R Luo,P Baldi,RK Brachmann,RH Lathrop,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

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Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: IEEE/ACM transactions on computational biology and

VOLUME: 3

Page Numbers: 114-25

Journal Abbreviation:

ISSN: 1545-5963

DAY: 3

MONTH: 12

YEAR: 2007

Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants. Information

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LANGUAGE: eng

NlmUniqueID: 101196755

Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: genetics

Chemical & Substance for Abstract: Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants. Information

Substance Name: Tumor Suppressor Protein p53

Registry Number: 0

Grant and Affiliation Information for Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants.

AFFILIATION: University of California, Irvine, CA 92697-3435, USA. sdanzige@uci.edu

Country: United States

AGENCY: United States NLM

GRANT: LM-07443-01

ACRONYM: LM

MEDLINETA: IEEE/ACM Trans Comput Biol Bio

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