Function of the Drosophila CPEB protein Orb2 in long-term courtship memory.

Function of the Drosophila CPEB protein Orb2 in long-term courtship memory. Research Abstract Details 

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Function of the Drosophila CPEB protein Orb2 in long-term courtship memory. Abstract Text:

Krystyna Keleman,Sebastian ,Mattias Alenius,Barry J Dickson,Krystyna Keleman,Sebastian Krüttner,Mattias Alenius,Barry J Dickson,

Both long-term behavioral memory and synaptic plasticity require protein synthesis, some of which may occur locally at specific synapses. Cytoplasmic polyadenylation element-binding (CPEB) proteins are thought to contribute to the local protein synthesis that underlies long-term changes in synaptic efficacy, but a role has not been established for them in the formation of long-term behavioral memory. We found that the Drosophila melanogaster CPEB protein Orb2 is acutely required for long-term conditioning of male courtship behavior. Deletion of the N-terminal glutamine-rich region of Orb2 resulted in flies that were impaired in their ability to form long-term, but not short-term, memory. Memory was restored by expressing Orb2 selectively in fruitless (fru)-positive gamma neurons of the mushroom bodies and by providing Orb2 function in mushroom bodies only during and shortly after training. Our data thus demonstrate that a CPEB protein is important in long-term memory and map the molecular, spatial and temporal requirements for its function in memory formation.

Function of the Drosophila CPEB protein Orb2 in long-term courtship memory. Publishing Authors By Initials

K Keleman,S ,M Alenius,BJ Dickson,K Keleman,S Krüttner,M Alenius,BJ Dickson,

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Function of the Drosophila CPEB protein Orb2 in long-term courtship memory. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature neuroscience

VOLUME: 10

Page Numbers: 1587-93

Journal Abbreviation: Nat. Neurosci.

ISSN: 1097-6256

DAY: 28

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: [1] Research Institute of Molecular Pathology, Dr. Bohr-gasse 7, A-1030 Vienna, Austria. [2] Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr-gasse 3-5, A-1030 Vienna, Austria.

Country: United States

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MEDLINETA: Nat Neurosci

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