Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation.

Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation. Research Abstract Details 

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Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation. Abstract Text:

R Takai,E Tanaka,T Miyazaki,M Suda,F Tashiro,

It has recently been reported that the members of 14-3-3 protein family participate in cell cycle control and associate with Raf, Bcr, Bcr-Abl, and polyomavirus middle tumor antigen (MT) as modulators of signal transduction. During cDNA cloning for the 17-kDa neuronal differentiation factor (K2 factor) secreted from rat hepatoma Kagura-2 (K2) cells from a K2 cDNA library using rat prepronerve growth factor (prepro NGF) cDNA as a probe, we obtained RNH-1 (rat NGF homologue) clone, which was identified as 14-3-3 beta cDNA, but not K2 factor, although no significant homology is present between 14-3-3 beta and prepro NGF cDNAs. RNH-1/14-3-3 beta gene was markedly expressed as a 2.9-kb mRNA in K2 cells and in newborn rat brain tissue. In PC12 cells the expression of this gene was down-regulated during the neuronal differentiation primed by NGF. The enforced expression of RNH-1/14-3-3 beta in PC12 and K2 cells conferred on them a higher sensitivity to NGF for neuronal differentiation and an intense growth ability in low serum medium, respectively. These results provide additional evidence that RNH-1/14-3-3 beta protein participates in cellular differentiation, proliferation and transformation through the signal transduction pathways of various growth factors.

Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation. Publishing Authors By Initials

R Takai,E Tanaka,T Miyazaki,M Suda,F Tashiro,

For similar enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research

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Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 118

Page Numbers: 1045-53

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Nov

YEAR: 1995

Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation. Keywords Mesh Terms:

KEYWORDS: Tyrosine 3-Monooxygenase

MESH TERMS: genetics

Chemical & Substance for Abstract: Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation. Information

Substance Name: Tyrosine 3-Monooxygenase

Registry Number: EC 1.14.16.2

Grant and Affiliation Information for Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation.

AFFILIATION: Department of Biological Science and Technology, Science University of Tokyo, Noda.

Country: JAPAN

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MEDLINETA: J Biochem

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