Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction.

Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Research Abstract Details 

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Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Abstract Text:

Kentaro Hosokawa,Fumio Arai,Hiroki Yoshihara,Yuka Nakamura,Yumiko Gomei,Hiroko Iwasaki,Kana Miyamoto,Haruko Shima,Keisuke Ito,Toshio Suda,Kentaro Hosokawa,Fumio Arai,Hiroki Yoshihara,Yuka Nakamura,Yumiko Gomei,Hiroko Iwasaki,Kana Miyamoto,Haruko Shima,Keisuke Ito,Toshio Suda,Kentaro Hosokawa,Fumio Arai,Hiroki Yoshihara,Yuka Nakamura,Yumiko Gomei,Hiroko Iwasaki,Kana Miyamoto,Haruko Shima,Keisuke Ito,Toshio Suda,

During postnatal life, the bone marrow (BM) supports both self-renewal and differentiation of hematopoietic stem cells (HSCs) in specialized niches, such as osteoblastic niche and vascular niche. A cell adhesion molecule, N-cadherin expressed in the HSCs and osteoblasts, suggesting that homophylic binding of N-cadherin induce the adhesion of HSCs to the niche cells. Here we demonstrate that an anti-cancer drug, 5-fuluorouracil induces reactive oxygen species (ROS) in HSCs, which suppressed N-cadherin expression. These events result in the shift of side population (SP) cells to non-SP cells, indicating that quiescent HSCs are detached from the niche. Administration of a potent anti-oxidant, N-acetyl cystein (NAC) suppressed the shift from SP cells. These data suggest that ROS suppressed the N-cadherin-mediated cell adhesion, and induce the exit of HSCs from the niche.

Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Publishing Authors By Initials

K Hosokawa,F Arai,H Yoshihara,Y Nakamura,Y Gomei,H Iwasaki,K Miyamoto,H Shima,K Ito,T Suda,K Hosokawa,F Arai,H Yoshihara,Y Nakamura,Y Gomei,H Iwasaki,K Miyamoto,H Shima,K Ito,T Suda,K Hosokawa,F Arai,H Yoshihara,Y Nakamura,Y Gomei,H Iwasaki,K Miyamoto,H Shima,K Ito,T Suda,

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Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 363

Page Numbers: 578-83

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 18

MONTH: 09

YEAR: 2007

Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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AFFILIATION: Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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